ITE

• CAT Number: I003584
• CAS Number: 448906-42-1
• Molecular Formula: C₁₄H₁₀N₂O₃S
• Molecular Weight: 286.3
• Purity: ≥95%
• Synonyms: methyl 2-(1H-indole-3-carbonyl)-1,3-thiazole-4-carboxylate
• Target: AhR
• Solubility: DMSO: ≥ 41 mg/mL
• Storage: Store at RT
• IC50: 0.2nM (for OVCAR-3 cell), 3 nM (Ki) [1]
• InChI: InChI=1S/C14H10N2O3S/c1-19-14(18)11-7-20-13(16-11)12(17)9-6-15-10-5-3-2-4-8(9)10/h2-7,15H,1H3
• InChIKey: KDDXOGDIPZSCTM-UHFFFAOYSA-N
• SMILES: COC(=O)C1=CSC(=N1)C(=O)C2=CNC3=CC=CC=C32

ITE (CAT: I003584) is a potent aryl hydrocarbon receptor (AhR) agonist that exerts its effects through interaction with the AhR receptor. With a high binding affinity (Ki) of 3 nM, ITE activates AhR-dependent signaling pathways, leading to a cascade of cellular responses. Notably, ITE has been shown to exhibit significant antiproliferative activity, particularly in OVCAR-3 cells, where it inhibits cell growth with an estimated IC50 of 0.2 nM. By modulating AhR activity, ITE holds promise as a valuable tool in research related to AhR-mediated processes and as a potential therapeutic agent targeting conditions where AhR signaling is implicated.

Reference

[1]. Cheng J, et al. Tryptophan derivatives regulate the transcription of Oct4 in stem-like cancer cells. Nat Commun. 2015 Jun 10;6:7209.
[2]. Quintana FJ, et al. An endogenous aryl hydrocarbon receptor ligand acts on dendritic cells and T cells to suppress experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A. 2010 Nov 30;107(48):20768-20773.