Itaconate-alkyne

• CAT Number: I045754
• CAS Number: 2454181-83-8
• Molecular Formula: C13H18O4
• Molecular Weight: 238.28
• Purity: ≥95%
• Synonyms: 2-methylidene-4-oct-7-ynoxy-4-oxobutanoic acid
• InChI: InChI=1S/C13H18O4/c1-3-4-5-6-7-8-9-17-12(14)10-11(2)13(15)16/h1H,2,4-10H2,(H,15,16)
• InChIKey: NPWMZOZWVAFQMP-UHFFFAOYSA-N
• SMILES: C=C(CC(=O)OCCCCCCC#C)C(=O)O

Itaconate-alkyne（Cat No.:I045754）is a chemically modified derivative of the endogenous metabolite itaconate, functionalized with an alkyne group for bioorthogonal chemistry applications. This modification preserves itaconate’s electrophilic character while enabling click chemistry labeling, allowing researchers to track and study its interactions within cellular systems. Itaconate-alkyne is widely used to investigate metabolic regulation, immunomodulation, and protein modification pathways, particularly in macrophage-mediated inflammation. By combining metabolic relevance with chemical versatility, itaconate-alkyne serves as a powerful probe for dissecting redox biology, innate immunity, and therapeutic targets in metabolic and inflammatory diseases.