IT1t dihydrochloride

• CAT Number: I010988
• CAS Number: 1092776-63-0
• Molecular Formula: C21H34N4S2.2HCl
• Molecular Weight: 479.57
• Purity: ≥95%
• Target: Chemokine Receptors
• Solubility: Soluble to 10 mM in DMSO and to 100 mM in water
• Storage: -20°C
• IUPAC Name: (6,6-dimethyl-5H-imidazo[2,1-b][1,3]thiazol-3-yl)methyl N,N'-dicyclohexylcarbamimidothioate;dihydrochloride
• InChI: InChI=1S/C21H34N4S2.2ClH/c1-21(2)15-25-18(14-27-20(25)24-21)13-26-19(22-16-9-5-3-6-10-16)23-17-11-7-4-8-12-17;;/h14,16-17H,3-13,15H2,1-2H3,(H,22,23);2*1H
• InChIKey: HFXJOXOIINQOEB-UHFFFAOYSA-N
• SMILES: CC1(CN2C(=CSC2=N1)CSC(=NC3CCCCC3)NC4CCCCC4)C.Cl.Cl

IT1t dihydrochloride（Cat No.:I010988） is a highly potent antagonist of the chemokine receptor CXCR4. It effectively inhibits the interaction between CXCL12 (also known as SDF-1) and CXCR4 with an IC50 of 2.1 nM. By blocking the CXCL12/CXCR4 signaling axis, IT1t dihydrochloride can interfere with cellular processes mediated by CXCR4, such as cell migration and metastasis. Its strong inhibitory activity against CXCR4 makes it a promising compound for potential therapeutic applications, particularly in the context of cancer and inflammatory diseases.