Ispronicline

• CAT Number: I007386
• CAS Number: 252870-53-4
• Molecular Formula: C14H22N2O
• Molecular Weight: 234.343
• Purity: ≥95%
• Target: nicotinic receptor partial agonist
• Solubility: Soluble in DMSO
• Storage: 0 - 4°C for short term , or -20°C for long term.
• IUPAC Name: (E,2S)-N-methyl-5-(5-propan-2-yloxypyridin-3-yl)pent-4-en-2-amine
• InChI: InChI=1S/C14H22N2O/c1-11(2)17-14-8-13(9-16-10-14)7-5-6-12(3)15-4/h5,7-12,15H,6H2,1-4H3/b7-5+/t12-/m0/s1
• InChIKey: RPCVIAXDAUMJJP-PZBABLGHSA-N
• SMILES: CC(C)OC1=CN=CC(=C1)C=CCC(C)NC

Ispronicline (Cat.No:I007386), also known as AZD3480; TC 1734; TC-0173, and RJR 1734, is a alpha4beta2 nicotinic acetylcholine receptor-selective agonist with cognition-enhancing and neuroprotective properties. Ispronicline is potentially useful for the treatment of attention-deficit/hyperactivity disorder in adults.

Reference

1:The α4β2 nicotine acetylcholine receptor agonist ispronicline induces c-Fos expression in selective regions of the rat forebrain. Jacobsen J, Hansen HH, Kiss A, Mikkelsen JD.Neurosci Lett. 2012 Apr 25;515(1):7-11. doi: 10.1016/j.neulet.2012.02.081. Epub 2012 Mar 3. PMID: 22414858 2:Effect of ispronicline, a neuronal nicotinic acetylcholine receptor partial agonist, in subjects with age associated memory impairment (AAMI). Dunbar GC, Inglis F, Kuchibhatla R, Sharma T, Tomlinson M, Wamsley J.J Psychopharmacol. 2007 Mar;21(2):171-8. Erratum in: J Psychopharmacol. 2008 Aug;22(6):698. PMID: 17329297 3:Cognitive enhancement in man with ispronicline, a nicotinic partial agonist. Dunbar GC, Kuchibhatla R.J Mol Neurosci. 2006;30(1-2):169-72. PMID: 17192668 4:Ispronicline: a novel alpha4beta2 nicotinic acetylcholine receptor-selective agonist with cognition-enhancing and neuroprotective properties. Lippiello P, Letchworth SR, Gatto GJ, Traina VM, Bencherif M.J Mol Neurosci. 2006;30(1-2):19-20. PMID: 17192610 5:Pharmacokinetics and safety profile of ispronicline (TC-1734), a new brain nicotinic receptor partial agonist, in young healthy male volunteers. Dunbar G, Demazières A, Monreal A, Cisterni C, Metzger D, Kuchibhatla R, Luthringer R.J Clin Pharmacol. 2006 Jul;46(7):715-26. PMID: 16809797 6:Ispronicline (Targacept). Geerts H.Curr Opin Investig Drugs. 2006 Jan;7(1):60-9. Review. PMID: 16425673