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Isosilybin B

Isosilybin B

  • CAT Number: I018330
  • CAS Number: 142796-22-3
  • Molecular Formula: C₂₅H₂₂O₁₀
  • Molecular Weight: 482.44
  • Purity: ≥95%
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Isosilybin B (Cat.No:I018330), a flavonolignan isolated from silymarin, has anti-prostate cancer (PCA) activity via inhibiting proliferation and inducing G1 phase arrest and apoptosis. Isosilybin B causes androgen receptor (AR) degradation.

Catalog Number I018330
CAS Number 142796-22-3
Molecular Formula

C₂₅H₂₂O₁₀

Purity 95%
Reference

[1]. Deep G, et al. Isosilybin B and isosilybin A inhibit growth, induce G1 arrest and cause apoptosis in human prostatecancer LNCaP and 22Rv1 cells. Carcinogenesis. 2007 Jul;28(7):1533-42.<br>[2]. Deep G, et al. Isosilybin B causes androgen receptor degradation in human prostate carcinoma cells via PI3K-Akt-Mdm2-mediated pathway. Oncogene. 2008 Jun 26;27(28):3986-98.

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