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Isoliquiritigenin

Isoliquiritigenin

  • CAT Number: I005698
  • CAS Number: 961-29-5
  • Molecular Formula: C15H12O4
  • Molecular Weight: 256.3
  • Purity: ≥95%
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Isoliquiritigenin(GU-17; Isoliquiritigen) is a licorice chalconoid, a type of natural phenols; is a sirtuin-activating compound.

Catalog Number I005698
CAS Number 961-29-5
Molecular Formula

C15H12O4

Purity 95%
Target Aldose reductase
Solubility DMSO 20 mg/ml; Water <0.1 mg/ml
Storage 3 years -20C powder
IC50 320 nM
InChIKey DXDRHHKMWQZJHT-FPYGCLRLSA-N
Reference

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[1]. Aida K, et al. Isoliquiritigenin: a new aldose reductase inhibitor from glycyrrhizae radix. Planta Med. 1990 Jun;56(3):254-8.
[2]. Sato Y, et al. Isoliquiritigenin, one of the antispasmodic principles of Glycyrrhiza ularensis roots, acts in the lower part of intestine. Biol Pharm Bull. 2007 Jan;30(1):145-9.&nbsp;
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<p>
[3]. Zhang X, Natural antioxidant-isoliquiritigenin ameliorates contractile dysfunction of hypoxic cardiomyocytes via AMPK signaling pathway. Mediators Inflamm. 2013;2013:390890.&nbsp;
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<p>
[4]. Qiao H, et al. Pharmacokinetics, biodistribution and bioavailability of isoliquiritigenin after intravenous and oral administration. Pharm Biol. 2013 Oct 9.&nbsp;
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[5]. Chen X, et al. Isoliquiritigenin inhibits the growth of multiple myeloma via blocking IL-6 signaling. J Mol Med (Berl). 2012 Nov;90(11):1311-9.
</p>

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