Isoginkgetin

• CAT Number: I004022
• CAS Number: 548-19-6
• Molecular Formula: C32H22O10
• Molecular Weight: 566.51
• Purity: ≥95%
• Target: MMP-9, Pre-mRNA Splicing
• Storage: -20°C
• IC50: 30 u M (Pre-mRNA Splicing)
• IUPAC Name: 8-[5-(5,7-dihydroxy-4-oxochromen-2-yl)-2-methoxyphenyl]-5,7-dihydroxy-2-(4-methoxyphenyl)chromen-4-one
• InChI: InChI=1S/C32H22O10/c1-39-18-6-3-15(4-7-18)26-14-24(38)31-22(36)12-21(35)29(32(31)42-26)19-9-16(5-8-25(19)40-2)27-13-23(37)30-20(34)10-17(33)11-28(30)41-27/h3-14,33-36H,1-2H3
• InChIKey: HUOOMAOYXQFIDQ-UHFFFAOYSA-N
• SMILES: COC1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C(=C(C=C3O)O)C4=C(C=CC(=C4)C5=CC(=O)C6=C(C=C(C=C6O5)O)O)OC

Isoginkgetin (CAT: I004022) is a specific inhibitor of matrix metalloproteinase-9 (MMP-9), which is an enzyme involved in the breakdown of extracellular matrix components. By inhibiting MMP-9, isoginkgetin can regulate the activity of this enzyme and potentially inhibit processes such as tissue remodeling, angiogenesis, and metastasis that are associated with MMP-9 activity. This property makes isoginkgetin an attractive compound for research focused on understanding and targeting MMP-9 in various pathological conditions, including cancer, inflammatory diseases, and tissue fibrosis.

Reference

1. Yoon SO et al. Isoginkgetin inhibits tumor cell invasion by regulating phosphatidylinositol 3-kinase/Akt-dependent matrix metalloproteinase-9 expression. Mol Cancer Ther. 2006 Nov;5(11):2666-75.
2. O/'Brien K et al. The biflavonoid isoginkgetin is a general inhibitor of Pre-mRNA splicing. J Biol Chem. 2008 Nov 28;283(48):33147-54.
3. Liu G et al. Isoginkgetin enhances adiponectin secretion from differentiated adiposarcoma cells via a novel pathway involving AMP-activated protein kinase. J Endocrinol. 2007 Sep;194(3):569-78.