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Isocarboxazid

Isocarboxazid

  • CAT Number: R006840
  • CAS Number: 59-63-2
  • Molecular Formula: C₁₂H₁₃N₃O₂
  • Molecular Weight: 231.25
  • Purity: ≥95%
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Isocarboxazid is a non-selective, irreversible monoamine oxidase inhibitor (MAOI) of the hydrazine class used as an antidepressant. Along with phenelzine and tranylcypromine, it is one of only three classical MAOIs still available for clinical use in the treatment of psychiatric disorders in the United States, though it is not as commonly employed in comparison to the others. Isocarboxazid is primarily used to treat mood and anxiety disorders. It has also been investigated in the treatment of Parkinson/’s disease and other dementia-related disorders.

Catalog Number R006840
CAS Number 59-63-2
Molecular Formula

C₁₂H₁₃N₃O₂

Purity 95%
Storage -20°C
Reference

</br>1:Vitamin B6 treatment of oedema induced by mirtazapine and isocarboxazid. Larsen JK, Bendsen BB, Bech P.Acta Psychiatr Scand. 2011 Jul;124(1):76-7; discussion 77. doi: 10.1111/j.1600-0447.2011.01695.x. Epub 2011 Mar 16. No abstract available. PMID: 21410439 </br>2:[Prolonged hyperthermia after isocarboxazid poisoning]. Ellervik C, Høgholm A.Ugeskr Laeger. 2003 Apr 28;165(18):1884-5. Danish. PMID: 12772401 </br>3:The reappearance of a monamine oxidase inhibitor (isocarboxazid) Shader RI, Greenblatt DJ.J Clin Psychopharmacol. 1999 Apr;19(2):105-6. No abstract available. PMID: 10211910 </br>4:Response to /Sertraline and isocarboxazid cause a serotonin syndrome/. Kirrane R, Bodner R, Lynch T.J Clin Psychopharmacol. 1995 Apr;15(2):144. No abstract available. PMID: 7782491 </br>5:Discontinuation of manufacture of isocarboxazid. Lieb J.JAMA. 1994 Dec 14;272(22):1722. No abstract available. PMID: 7966911 </br>6:Sertraline and isocarboxazid cause a serotonin syndrome. Brannan SK, Talley BJ, Bowden CL.J Clin Psychopharmacol. 1994 Apr;14(2):144-5. No abstract available. PMID: 8195456 </br>7:The effect of the monoamine oxidase inhibitor isocarboxazid on the canine metabolism of the cell-differentiating agent hexamethylene bisacetamide. Conley BA, Sewack GF, Egorin MJ, Subramanyam B, Page JG, Grieshaber CK.Cancer Chemother Pharmacol. 1991;28(1):33-8. PMID: 2040031 </br>8:Disruption of FR-40 by 5-HT agonists. II. Effects of chronic phenelzine or isocarboxazid. Shukla R, Goudreau J, Mackenzie-Taylor D, Rech RH.Pharmacol Biochem Behav. 1989 Oct;34(2):283-7. PMID: 2622983 </br>9:Interaction between dextromethorphan and monoamine oxidase inhibitor therapy with isocarboxazid. Sovner R, Wolfe J.N Engl J Med. 1988 Dec 22;319(25):1671. No abstract available. PMID: 3200285 </br>10:A trial of isocarboxazid in the treatment of bulimia nervosa. Kennedy SH, Piran N, Warsh JJ, Prendergast P, Mainprize E, Whynot C, Garfinkel PE.J Clin Psychopharmacol. 1988 Dec;8(6):391-6. Erratum in: J Clin Psychopharmacol 1989 Feb;9(1):3. PMID: 3069879

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