Isobavachalcone

• CAT Number: I002599
• CAS Number: 20784-50-3
• Molecular Formula: C20H20O4
• Molecular Weight: 324.4
• Purity: ≥95%
• Target: Akt
• Solubility: DMSO: ≤ 11 mg/mL
• Storage: Store at -20°C
• IUPAC Name: (E)-1-[2,4-dihydroxy-3-(3-methylbut-2-enyl)phenyl]-3-(4-hydroxyphenyl)prop-2-en-1-one
• InChI: InChI=1S/C20H20O4/c1-13(2)3-9-16-19(23)12-10-17(20(16)24)18(22)11-6-14-4-7-15(21)8-5-14/h3-8,10-12,21,23-24H,9H2,1-2H3/b11-6+
• InChIKey: DUWPGRAKHMEPCM-IZZDOVSWSA-N
• SMILES: CC(=CCC1=C(C=CC(=C1O)C(=O)C=CC2=CC=C(C=C2)O)O)C

Isobavachalcone (Cat.No:I002599) is a naturally occurring chalcone compound found in several plant species. It exhibits various biological activities, including anti-inflammatory, antioxidant, anticancer, and antimicrobial properties. Isobavachalcone has shown potential in inhibiting the growth of cancer cells, reducing inflammation, and protecting against oxidative stress, making it a promising candidate for further research and development.

Reference

1:Isobavachalcone Attenuates MPTP-Induced Parkinson/’s Disease in Mice by Inhibition of Microglial Activation through NF-κB Pathway. Jing H, Wang S, Wang M, Fu W, Zhang C, Xu D.PLoS One. 2017 Jan 6;12(1):e0169560. doi: 10.1371/journal.pone.0169560. eCollection 2017. PMID: 28060896 Free PMC Article2:Isobavachalcone induces the apoptosis of gastric cancer cells via inhibition of the Akt and Erk pathways. Jin X, Shi YI.Exp Ther Med. 2016 Feb;11(2):403-408. Epub 2015 Dec 1. PMID: 26893622 Free PMC Article3:Cytotoxicity of three naturally occurring flavonoid derived compounds (artocarpesin, cycloartocarpesin and isobavachalcone) towards multi-factorial drug-resistant cancer cells. Kuete V, Mbaveng AT, Zeino M, Fozing CD, Ngameni B, Kapche GD, Ngadjui BT, Efferth T.Phytomedicine. 2015 Nov 15;22(12):1096-102. doi: 10.1016/j.phymed.2015.07.006. Epub 2015 Aug 11. PMID: 26547532 4:Enzymatic synthesis of novel isobavachalcone glucosides via a UDP-glycosyltransferase. Li HM, Lee JK, Nie LJ, Huo Q, Ma T, Sohng JK, Hong YS, Wu CZ.Arch Pharm Res. 2015 Dec;38(12):2208-15. doi: 10.1007/s12272-015-0658-8. Epub 2015 Sep 15. PMID: 26374247 5:Isobavachalcone attenuates lipopolysaccharide-induced ICAM-1 expression in brain endothelial cells through blockade of toll-like receptor 4 signaling pathways. Lee KM, Kim JM, Baik EJ, Ryu JH, Lee SH.Eur J Pharmacol. 2015 May 5;754:11-8. doi: 10.1016/j.ejphar.2015.02.013. Epub 2015 Feb 19. PMID: 25704611 6:Determination of isobavachalcone in rat plasma by LC-MS/MS and its application to a pharmacokinetic study. Ma T, Nie LJ, Li HM, Huo Q, Zhang YX, Wu CZ.J Pharm Biomed Anal. 2015 Mar 25;107:50-5. doi: 10.1016/j.jpba.2014.12.023. Epub 2014 Dec 22. PMID: 25575171 7:Structural elucidation of in vivo metabolites of isobavachalcone in rat by LC-ESI-MS(n) and LC-NMR. Su S, Wang Y, Bai L, Xia B, Li X, Tang Y, Xu P, Xue M.J Pharm Biomed Anal. 2015 Feb;104:38-46. doi: 10.1016/j.jpba.2014.11.010. Epub 2014 Nov 15. PMID: 25459757 8:Study on structural and spectral properties of isobavachalcone and 4-hydroxyderricin by computational method. Rong Y, Wu J, Liu X, Zhao B, Wang Z.Spectrochim Acta A Mol Biomol Spectrosc. 2014 May 21;126:254-9. doi: 10.1016/j.saa.2014.02.013. Epub 2014 Feb 18. PMID: 24607475 9:Isobavachalcone and bavachinin from Psoraleae Fructus modulate Aβ42 aggregation process through different mechanisms in vitro. Chen X, Yang Y, Zhang Y.FEBS Lett. 2013 Sep 17;587(18):2930-5. doi: 10.1016/j.febslet.2013.07.037. Epub 2013 Jul 29. PMID: 23907009 Free Article10:Isobavachalcone suppresses expression of inducible nitric oxide synthase induced by Toll-like receptor agonists. Shin HJ, Shon DH, Youn HS.Int Immunopharmacol. 2013 Jan;15(1):38-41. doi: 10.1016/j.intimp.2012.11.005. Epub 2012 Nov 16. PMID: 23164691