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Isavuconazonium sulfate

Isavuconazonium sulfate

  • CAT Number: I007373
  • CAS Number: 946075-13-4
  • Molecular Formula: C35H36F2N8O9S2
  • Molecular Weight: 814.837
  • Purity: ≥95%
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Isavuconazole (BAL4815; trade name Cresemba) is a triazole antifungal drug. Its prodrug, isavuconazonium sulfate (BAL8557), was granted approval by the U.S. Food and Drug Administration (FDA) on March 6, 2015. Isavuconazole has been approved for treatment of invasive aspergillosis and invasive mucormycosis in adults ages 18 years and older. Both infections are caused by mold and fungi common to the environment, and occur in individuals who are immunosuppressed or have other complicating conditions, such as diabetes or lung disease.

Catalog Number I007373
CAS Number 946075-13-4
Molecular Formula

C35H36F2N8O9S2

Purity 95%
Solubility Soluble in DMSO, not in water
Storage 0 - 4°C for short term , or -20°C for long term.
IUPAC Name [2-[1-[1-[(2R,3R)-3-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]-2-(2,5-difluorophenyl)-2-hydroxybutyl]-1,2,4-triazol-4-ium-4-yl]ethoxycarbonyl-methylamino]pyridin-3-yl]methyl 2-(methylamino)acetate;hydrogen sulfate
InChI InChI=1S/C35H35F2N8O5S.H2O4S/c1-22(33-42-30(18-51-33)25-9-7-24(15-38)8-10-25)35(48,28-14-27(36)11-12-29(28)37)19-45-21-44(20-41-45)23(2)50-34(47)43(4)32-26(6-5-13-40-32)17-49-31(46)16-39-3;1-5(2,3)4/h5-14,18,20-23,39,48H,16-17,19H2,1-4H3;(H2,1,2,3,4)/q+1;/p-1/t22-,23?,35+;/m0./s1
InChIKey LWXUIUUOMSMZKJ-KLFWAVJMSA-M
SMILES CC(C1=NC(=CS1)C2=CC=C(C=C2)C#N)C(CN3C=[N+](C=N3)C(C)OC(=O)N(C)C4=C(C=CC=N4)COC(=O)CNC)(C5=C(C=CC(=C5)F)F)O.OS(=O)(=O)[O-]
Reference

</br>1:Physical compatibility of isavuconazonium sulfate with select i.v. drugs during simulated Y-site administration. So W, Kim L, Thabit AK, Nicolau DP, Kuti JL.Am J Health Syst Pharm. 2017 Jan 1;74(1):e55-e63. doi: 10.2146/ajhp150733. Epub 2016 Dec 22. PMID: 28007722 </br>2:Isavuconazonium sulfate: a triazole prodrug for invasive fungal infections. Murrell D, Bossaer JB, Carico R, Harirforoosh S, Cluck D.Int J Pharm Pract. 2017 Feb;25(1):18-30. doi: 10.1111/ijpp.12302. Epub 2016 Aug 29. Review. PMID: 27569742 </br>3:Isavuconazonium sulfate: a new agent for the treatment of invasive aspergillosis and invasive mucormycosis. Kovanda LL, Maher R, Hope WW.Expert Rev Clin Pharmacol. 2016 Jul;9(7):887-97. doi: 10.1080/17512433.2016.1185361. Epub 2016 May 21. Review. PMID: 27160418 </br>4:Isavuconazonium sulfate (Cresemba)–a new antifungal. [No authors listed]Med Lett Drugs Ther. 2016 Mar 14;58(1490):37-8. Review. No abstract available. PMID: 26963156 </br>5:Isavuconazonium sulfate for the treatment of fungal infection. Walker RC, Zeuli JD, Temesgen Z.Drugs Today (Barc). 2016 Jan;52(1):7-16. doi: 10.1358/dot.2016.52.1.2404002. Review. PMID: 26937491 </br>6:Ceftazidime pentahydrate/avibactam sodium, Isavuconazonium sulfate, and Daclatasvir dihydrochloride. Hussar DA, Friedman J.J Am Pharm Assoc (2003). 2016 Jan;56(1):100-3. doi: 10.1016/j.japh.2015.12.003. No abstract available. PMID: 26802929 </br>7:Isavuconazonium sulfate approved for invasive fungal infections. Traynor K.Am J Health Syst Pharm. 2015 Apr 15;72(8):592. doi: 10.2146/news150027. No abstract available. PMID: 25825173

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