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IR415

IR415

  • CAT Number: I015555
  • CAS Number: 452967-14-5
  • Molecular Formula: C₁₃H₁₄F₂N₄S
  • Molecular Weight: 296.34
  • Purity: ≥95%
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IR415 is a potent anti-HBV agent and inhibits HBV replication by blocking the HBx activity. IR415 selectively interacts with HBx (Kd=2 nM) and blocks HBV-mediated RNAi suppression, reverses the inhibitory effect of HBx protein on the activity of the dicer endoribonuclease[1]. HBx: hepatitis B virus X protein.<br>Hepatitis B virus X protein (HBx) as a suppressor of host defenses consisting of RNAi-based silencing of viral genes[1].IR415 (50-200 μM) has a dose-dependent inhibitory effect on HBx, with a minimal effective concentration of 50 μM in HepG2/GFP-shRNA line transfected with HBx[1].

Catalog Number I015555
CAS Number 452967-14-5
Molecular Formula

C₁₃H₁₄F₂N₄S

Purity 95%
Reference

[1]. Ghosh S, et al. An RNAi-based high-throughput screening assay to identify small molecule inhibitors of hepatitis B virus replication.J Biol Chem. 2017 Jul 28;292(30):12577-12588.

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