IQ-1S free acid

• CAT Number: I002766
• CAS Number: 23146-22-7
• Molecular Formula: C15H9N3O
• Molecular Weight: 247.25
• Purity: ≥95%
• Target: JNK inhibitor
• Solubility: Soluble to 20 mM in DMSO with gentle warming
• Storage: -20°C

IQ-1S (free acid) (CAT: I002766) is a selective inhibitor of JNK kinases, with a higher preference for JNK3. It binds to JNK1, JNK2, and JNK3 with Kd values of 390 nM, 360 nM, and 87 nM, respectively [1]. IQ-1S exhibits inhibitory effects on the production of proinflammatory cytokines and nitric oxide in vitro, making it a potential anti-inflammatory agent. In vivo, studies have demonstrated its ability to attenuate the severity of collagen-induced arthritis and inhibit murine delayed-type Doxycycline hypersensitivity.

Reference

[1]. Igor A. Schepetkin et al. Anti-Inflammatory Effects and Joint Protection in Collagen-Induced Arthritis after Treatment with IQ-1S, a Selective c-Jun N-Terminal Kinase Inhibitor. J Pharmacol Exp Ther, 2015 Jun, 353(3): 505-516.

[2]. Dmitriy N. Atochin et al.A novel dual NO-donating oxime and c-Jun N-terminal kinase inhibitor protects against cerebral ischemia-reperfusion injury in mice. Neurosci Lett.2016 Apr 8;618:45-9.

[3]. Igor A. Schepetkin et al. Identification and Characterization of a Novel Class of c-Jun N-terminal Kinase Inhibitors. Mol Pharmacol, 2012 Jun, 81(6): 832-845.