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IOWH-032

IOWH-032

  • CAT Number: I000692
  • CAS Number: 1191252-49-9
  • Molecular Formula: C22H15Br2N3O4
  • Molecular Weight: 545.18
  • Purity: ≥95%
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IOWH-032 (Cat.No:I000692) is a potent and selective inhibitor of spleen tyrosine kinase (SYK), a key signaling molecule involved in immune cell activation and inflammatory responses. By inhibiting SYK, IOWH-032 modulates immune system function and shows potential therapeutic effects in autoimmune diseases, allergic disorders, and certain types of cancer.

Catalog Number I000692
CAS Number 1191252-49-9
Molecular Formula

C22H15Br2N3O4

Purity 95%
Target CFTR
Solubility in DMSO > 10 mM
Storage Store at -20℃
IC50 1.01 uM (CHO-CFTR FLIPR) [1]
IUPAC Name 3-(3,5-dibromo-4-hydroxyphenyl)-N-[(4-phenoxyphenyl)methyl]-1,2,4-oxadiazole-5-carboxamide
InChI InChI=1S/C22H15Br2N3O4/c23-17-10-14(11-18(24)19(17)28)20-26-22(31-27-20)21(29)25-12-13-6-8-16(9-7-13)30-15-4-2-1-3-5-15/h1-11,28H,12H2,(H,25,29)
InChIKey DSFNLJXHXBIKDS-UHFFFAOYSA-N
SMILES C1=CC=C(C=C1)OC2=CC=C(C=C2)CNC(=O)C3=NC(=NO3)C4=CC(=C(C(=C4)Br)O)Br
Reference

<p style=/line-height:25px/>
<br>[1]. Doyle K, et al. Inhibitors Of The CFTR Chloride Ion Channel As Potential Treatment For
Acute Secretory Diarrhea: Development Of 5-membered Heterocycles Suitable For Pre-clinical Evaluation

<br>[2]. de Hostos EL, et al. Developing novel antisecretory drugs to treat infectious diarrhea. Future Med Chem. 2011 Aug;3(10):1317-25.

</p>

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