Iopamidol

• CAT Number: A000093
• CAS Number: 60166-93-0
• Molecular Formula: C17H22I3N3O8
• Molecular Weight: 777.09
• Purity: ≥95%
• Storage: Store at -20°C
• InChI: 1S/C17H22I3N3O8/c1-6(28)15(29)23-14-12(19)9(16(30)21-7(2-24)3-25)11(18)10(13(14)20)17(31)22-8(4-26)5-27/h6-8,24-28H,2-5H2,1H3,(H,21,30)(H,22,31)(H,23,29)/t6-/m0/s1
• InChIKey: XQZXYNRDCRIARQ-LURJTMIESA-N
• SMILES: CC(C(=O)NC1=C(C(=C(C(=C1I)C(=O)NC(CO)CO)I)C(=O)NC(CO)CO)I)O

Iopamidol, also known as Gastromiro and SQ-13396, is a non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiological procedures.

Reference

1: Wu Y, Zhou IY, Igarashi T, Longo DL, Aime S, Sun PZ. A generalized ratiometric
chemical exchange saturation transfer (CEST) MRI approach for mapping renal pH
using iopamidol. Magn Reson Med. 2017 Jul 7. doi: 10.1002/mrm.26817. [Epub ahead
of print] PubMed PMID: 28686805.

2: Rogers D, Sheth C, Eisenmenger L, Mignogna E, Winter T. Iopamidol as an oral
contrast media for computed tomography: a taste comparison to iohexol,
diatrizoate sodium, and barium sulfate. Abdom Radiol (NY). 2017 Jul 1. doi:
10.1007/s00261-017-1226-0. [Epub ahead of print] PubMed PMID: 28669111.

3: Tian FX, Xu B, Lin YL, Hu CY, Zhang TY, Xia SJ, Chu WH, Gao NY.
Chlor(am)ination of iopamidol: Kinetics, pathways and disinfection by-products
formation. Chemosphere. 2017 Oct;184:489-497. doi:
10.1016/j.chemosphere.2017.06.012. Epub 2017 Jun 5. PubMed PMID: 28618281.

4: Lévesque AM, Yang CD, Elchebly C, Doré M. Hepatotoxicity associated with
iopamidol. Am J Health Syst Pharm. 2017 May 15;74(10):636-640. doi:
10.2146/ajhp160753. PubMed PMID: 28483940.

5: Hu J, Dong H, Qu J, Qiang Z. Enhanced degradation of iopamidol by
peroxymonosulfate catalyzed by two pipe corrosion products (CuO and δ-MnO(2)).
Water Res. 2017 Apr 1;112:1-8. doi: 10.1016/j.watres.2017.01.025. Epub 2017 Jan
16. PubMed PMID: 28110150.

6: Bellich B, Di Fonzo S, Tavagnacco L, Paolantoni M, Masciovecchio C, Bertolotti
F, Giannini G, De Zorzi R, Geremia S, Maiocchi A, Uggeri F, Masciocchi N, Cesàro
A. Myelography Iodinated Contrast Media. 2. Conformational Versatility of
Iopamidol in the Solid State. Mol Pharm. 2017 Feb 6;14(2):468-477. doi:
10.1021/acs.molpharmaceut.6b00902. Epub 2017 Jan 18. PubMed PMID: 28059514.

7: Rosenberg C, Martínez-Rodrigo JJ, Lonjedo Vicent E, Macho J, Lim L, Todoran
TM; Peripheral Discomfort Study Investigator Panel. Randomized, Double-Blind
Study Comparing Patient Comfort and Safety Between Iodixanol 320 mg I/mL and
Iopamidol 370 mg I/mL in Patients Undergoing Peripheral Arteriography – The
COMFORT II Trial. J Invasive Cardiol. 2017 Jan;29(1):9-15. PubMed PMID: 28045670.

8: Borrelli MP, Setacci F, de Donato G, Galzerano G, Benevento D, Mele M,
Rosadini D, Messina G, Setacci C. Patient Discomfort during Carotid Artery
Stenting: A Comparison Study between Iodixanol versus Iopamidol. Ann Vasc Surg.
2017 Feb;39:167-172. doi: 10.1016/j.avsg.2016.04.018. Epub 2016 Aug 10. PubMed
PMID: 27521830.

9: Matsushita T, Hashizuka M, Kuriyama T, Matsui Y, Shirasaki N. Use of
orbitrap-MS/MS and QSAR analyses to estimate mutagenic transformation products of
iopamidol generated during ozonation and chlorination. Chemosphere. 2016
Apr;148:233-40. doi: 10.1016/j.chemosphere.2016.01.037. Epub 2016 Jan 23. PubMed
PMID: 26807944.

10: Moon BF, Jones KM, Chen LQ, Liu P, Randtke EA, Howison CM, Pagel MD. A
comparison of iopromide and iopamidol, two acidoCEST MRI contrast media that
measure tumor extracellular pH. Contrast Media Mol Imaging. 2015
Nov-Dec;10(6):446-55. doi: 10.1002/cmmi.1647. Epub 2015 Jun 25. PubMed PMID:
26108564; PubMed Central PMCID: PMC4691225.