Ionomycin free acid

• CAT Number: I010507
• CAS Number: 56092-81-0
• Molecular Formula: C41H72O9
• Molecular Weight: 709
• Purity: ≥95%
• Target: Calcium Channel
• Solubility: Soluble to 10 mM in ethanol and to 10 mM in DMSO
• Storage: Store at -20°C
• IUPAC Name: (4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-11,19,21-trihydroxy-22-[(2S,5S)-5-[(2R,5S)-5-[(1R)-1-hydroxyethyl]-5-methyloxolan-2-yl]-5-methyloxolan-2-yl]-4,6,8,12,14,18,20-heptamethyl-9-oxodocosa-10,16-dienoic acid
• InChI: InChI=1S/C41H72O9/c1-25(21-29(5)34(43)24-35(44)30(6)22-27(3)20-26(2)14-15-38(46)47)12-11-13-28(4)39(48)31(7)36(45)23-33-16-18-41(10,49-33)37-17-19-40(9,50-37)32(8)42/h11,13,24-33,36-37,39,42-43,45,48H,12,14-23H2,1-10H3,(H,46,47)/b13-11+,34-24-/t25-,26-,27+,28-,29-,30+,31+,32-,33+,36+,37-,39-,40+,41+/m1/s1
• InChIKey: PGHMRUGBZOYCAA-KCZOVTJBSA-N
• SMILES: CC(CCC(=O)O)CC(C)CC(C)C(=O)C=C(C(C)CC(C)CC=CC(C)C(C(C)C(CC1CCC(O1)(C)C2CCC(O2)(C)C(C)O)O)O)O

Ionomycin free acid (Cat.No:I010507) is a calcium ionophore compound widely used in research to study cellular calcium signaling. It facilitates the transport of calcium ions across cell membranes, leading to an increase in intracellular calcium levels. Ionomycin free acid is particularly valuable in experiments that require precise control of intracellular calcium concentrations.

Reference

Ionomycin, a new polyether antibiotic. Liu W-C. et al. J. Antibiot. 1978, 31, 815.

Characterization of ionomycin as a calcium ionophore. Liu C. M. & Herman T. E. J. Biol. Chem. 1978, 253, 5892.