Iohexol

• CAT Number: I004490
• CAS Number: 66108-95-0
• Molecular Formula: C19H26I3N3O9
• Molecular Weight: 821.14
• Purity: ≥95%
• Target: Others
• Solubility: DMSO:45mg/mL
• Storage: Room Temperature
• IUPAC Name: 5-[acetyl(2,3-dihydroxypropyl)amino]-1-N,3-N-bis(2,3-dihydroxypropyl)-2,4,6-triiodobenzene-1,3-dicarboxamide
• InChI: InChI=1S/C19H26I3N3O9/c1-8(29)25(4-11(32)7-28)17-15(21)12(18(33)23-2-9(30)5-26)14(20)13(16(17)22)19(34)24-3-10(31)6-27/h9-11,26-28,30-32H,2-7H2,1H3,(H,23,33)(H,24,34)
• InChIKey: NTHXOOBQLCIOLC-UHFFFAOYSA-N
• SMILES: CC(=O)N(CC(CO)O)C1=C(C(=C(C(=C1I)C(=O)NCC(CO)O)I)C(=O)NCC(CO)O)I

Iohexol (Cat No.: I004490) is a raw material for the production of water-soluble, non-ionic X-CT contrast agents in pharmaceutical factories. This contrast agent is usually injected into the vein before CT contrast diagnosis and is used for angiography, urinary system, spinal cord, hip joint, and lymphatic system contrast. It has the advantages of low contrast density, low toxicity, and good tolerance. It is currently the best One of the most common contrast agents, developed countries have completely replaced ionic contrast agents with it. It is also a diagnostic drug.

Reference

1:Validation of a routine two-sample iohexol plasma clearance assessment of GFR and an evaluation of common endogenous markers in a rat model of CKD. Turner ME, Laverty KJ, Jeronimo PS, Kaufmann M, Jones G, White CA, Holden RM, Adams MA.Physiol Rep. 2017 May;5(9). pii: e13205. doi: 10.14814/phy2.13205. PMID: 28483858 Free PMC Article2:Iohexol Clearance for Determination of Glomerular Filtration Rate in Cynomolgus Monkeys (Macaca fascicularis). Zhang C, Ding S, Fang Y, Zhang L, Hu W, Lu J, Jing T, Tao Y, Zhang X.J Am Assoc Lab Anim Sci. 2017 Apr 25. doi: no_doi/1493126951393. [Epub ahead of print] PMID: 28443538 3:Comparison of the nephrotoxic effects of iodixanol versus iohexol in patients with chronic heart failure undergoing coronary angiography or angioplasty. Song T, Song M, Ge Z, Li Y, Shi P, Sun M.J Interv Cardiol. 2017 Apr 19. doi: 10.1111/joic.12381. [Epub ahead of print] PMID: 28421628 4:Renal Response to a Protein Load in Healthy Young Adults as Determined by Iohexol Infusion Clearance, Cimetidine-Inhibited Creatinine Clearance, and Cystatin C Estimated Glomerular Filtration Rate. Rodenbach KE, Fuhrman DY, Maier PS, Schwartz GJ.J Ren Nutr. 2017 Apr 4. pii: S1051-2276(17)30028-6. doi: 10.1053/j.jrn.2017.01.021. [Epub ahead of print] PMID: 28389059 5:Routinely measured iohexol glomerular filtration rate versus creatinine-based estimated glomerular filtration rate as predictors of mortality in patients with advanced chronic kidney disease: a Swedish Chronic Kidney Disease Registry cohort study. Methven S, Gasparini A, Carrero JJ, Caskey FJ, Evans M.Nephrol Dial Transplant. 2017 Apr 1;32(suppl_2):ii170-ii179. doi: 10.1093/ndt/gfw457. PMID: 28339801 6:A simple LC-MS method for the determination of iohexol and iothalamate in serum, using ioversol as an internal standard. Nyssen L, Delanaye P, Le Goff C, Peeters S, Cavalier É.Clin Chim Acta. 2016 Dec 1;463:96-102. doi: 10.1016/j.cca.2016.10.021. Epub 2016 Oct 15. PMID: 27756544 7:Investigation of the formation of the [2(iohexol) + Mg]2+ complex and its fragmentation in electrospray ionization tandem mass spectrometry. Guo M, Yin D, Han J, Li X, Zhang L, Du Y, Wang H, Guo C, Tang D.Rapid Commun Mass Spectrom. 2017 Jan 15;31(1):9-15. doi: 10.1002/rcm.7765. PMID: 27747964 8:Iohexol plasma clearance for measuring glomerular filtration rate in clinical practice and research: a review. Part 2: Why to measure glomerular filtration rate with iohexol? Delanaye P, Melsom T, Ebert N, Bäck SE, Mariat C, Cavalier E, Björk J, Christensson A, Nyman U, Porrini E, Remuzzi G, Ruggenenti P, Schaeffner E, Soveri I, Sterner G, Eriksen BO, Gaspari F.Clin Kidney J. 2016 Oct;9(5):700-4. doi: 10.1093/ckj/sfw071. Epub 2016 Sep 9. PMID: 27679716 Free PMC Article9:Iohexol plasma clearance for measuring glomerular filtration rate in clinical practice and research: a review. Part 1: How to measure glomerular filtration rate with iohexol? Delanaye P, Ebert N, Melsom T, Gaspari F, Mariat C, Cavalier E, Björk J, Christensson A, Nyman U, Porrini E, Remuzzi G, Ruggenenti P, Schaeffner E, Soveri I, Sterner G, Eriksen BO, Bäck SE.Clin Kidney J. 2016 Oct;9(5):682-99. doi: 10.1093/ckj/sfw070. Epub 2016 Aug 23. PMID: 27679715 Free PMC Article10:Intestinal permeability to iohexol as an in vivo marker of chemotherapy-induced gastrointestinal toxicity in Sprague-Dawley rats. Forsgård RA, Korpela R, Holma R, Lindén J, Frias R, Spillmann T, Österlund P.Cancer Chemother Pharmacol. 2016 Oct;78(4):863-74. doi: 10.1007/s00280-016-3150-3. Epub 2016 Sep 2. PMID: 27590707 Free PMC Article