Iodipamide

• CAT Number: R009675
• CAS Number: 606-17-7
• Molecular Formula: C20H14I6N2O6
• Molecular Weight: 1139.767
• Purity: ≥95%
• Storage: -20°C
• IUPAC Name: 3-[[6-(3-carboxy-2,4,6-triiodoanilino)-6-oxohexanoyl]amino]-2,4,6-triiodobenzoic acid
• InChI: InChI=1S/C20H14I6N2O6/c21-7-5-9(23)17(15(25)13(7)19(31)32)27-11(29)3-1-2-4-12(30)28-18-10(24)6-8(22)14(16(18)26)20(33)34/h5-6H,1-4H2,(H,27,29)(H,28,30)(H,31,32)(H,33,34)
• InChIKey: FFINMCNLQNTKLU-UHFFFAOYSA-N
• SMILES: C1=C(C(=C(C(=C1I)NC(=O)CCCCC(=O)NC2=C(C=C(C(=C2I)C(=O)O)I)I)I)C(=O)O)I

Iodipamide is a molecule used as a contrast medium. When administered in vivo, iodipamide is removed from the liver and secreted into the biliary tract. Like other organic iodine compounds, this agent blocks x-rays and appears opaque on x-ray film; thereby it enhances the visibility of the bile ducts and gallbladder during cholangiography and cholecystography procedures.

Reference

1:[Hyponatremia induced by iodipamide: three cases report]. Huang H, Zeng JP, Long Y.Zhonghua Xin Xue Guan Bing Za Zhi. 2009 Jul;37(7):621. Chinese. No abstract available. PMID: 19961734 2:Liver enhancement techniques in computed tomography. A comparison of intravenous bolus, computed tomographic portography, and iodipamide ethyl ester particle injections in a canine model. Lee FT Jr, Sproat IA, Rappe AH, Violante MR, Bronson JP.Invest Radiol. 1994 Jun;29 Suppl 2:S289-92. No abstract available. PMID: 7928259 3:Potentiometric determination of iodipamide using an iodipamide ion-selective electrode. Yao SZ, Liu DZ, Nie LH.J Pharm Biomed Anal. 1990;8(4):373-7. No abstract available. PMID: 2100212 4:Accumulation and elimination of particulate iodipamide ethyl ester in the lungs and kidneys of the rat. A morphological study. Lauteala L, Kormano M, Violante MR.APMIS. 1988 Jul;96(7):660-6. PMID: 3408591 5:Uptake and dissolution of particulate iodipamide ethyl ester in the spleen. A morphologic study. Lauteala L, Kormano M, Violante MR.Invest Radiol. 1987 Oct;22(10):829-35. PMID: 3429178 6:Computed tomographic enhancement of liver and spleen in the dog with iodipamide ethyl ester particulate suspensions. Sands MS, Violante MR, Gadeholt G.Invest Radiol. 1987 May;22(5):408-16. PMID: 3597009 7:Response of white blood cells to iodipamide ethyl ester particles. Lauteala L, Kormano M, Violante MR.Invest Radiol. 1986 Jul;21(7):562-5. PMID: 3733383 8:Iodipamide uptake by rat liver plasma membrane vesicles enriched in the sinusoidal fraction: evidence for a carrier-mediated transport dependent on membrane potential. Täfler M, Ziegler K, Frimmer M.Biochim Biophys Acta. 1986 Feb 13;855(1):157-68. PMID: 3942739 9:Properties of iodipamide uptake by isolated rat hepatocytes. Joppen C, Petzinger E, Frimmer M.Naunyn Schmiedebergs Arch Pharmacol. 1985 Dec;331(4):393-7. PMID: 4094628 10:Effect of intravenously administered iodipamide ethyl ester particles on rat liver morphology. Lauteala L, Kormano M, Violante MR.Invest Radiol. 1984 Mar-Apr;19(2):133-41. PMID: 6533104