INK-128

• CAT Number: I000862
• CAS Number: 1224844-38-5
• Molecular Formula: C₁₅H₁₅N₇O
• Molecular Weight: 309.33
• Purity: ≥95%
• Target: mTOR
• Solubility: DMSO 62 mg/ml; Water <1 mg/ml
• Storage: 3 years -20℃ powder
• IC50: 1 nM [1]
• IUPAC Name: 5-(4-amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)-1,3-benzoxazol-2-amine
• InChI: InChI=1S/C15H15N7O/c1-7(2)22-14-11(13(16)18-6-19-14)12(21-22)8-3-4-10-9(5-8)20-15(17)23-10/h3-7H,1-2H3,(H2,17,20)(H2,16,18,19)
• InChIKey: GYLDXIAOMVERTK-UHFFFAOYSA-N
• SMILES: CC(C)N1C2=C(C(=N1)C3=CC4=C(C=C3)OC(=N4)N)C(=NC=N2)N

INK-128 (Cat.No:I000862) is a potent and selective inhibitor of the mechanistic target of rapamycin (mTOR) kinase. It blocks the activity of both mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2), which play crucial roles in cell growth and survival. INK-128 has demonstrated anticancer activity and is being investigated as a potential treatment for various types of cancer.

Reference

1:Dual mTORC1/2 inhibition by INK-128 results in antitumor activity in preclinical models of osteosarcoma. Jiang H, Zeng Z.Biochem Biophys Res Commun. 2015 Dec 4-11;468(1-2):255-61. doi: 10.1016/j.bbrc.2015.10.119. Epub 2015 Oct 26. PMID: 26514724 2:Dual targeting of mTORC1 and mTORC2 by INK-128 potently inhibits human prostate cancer cell growth in vitro and in vivo. Jiang SJ, Wang S.Tumour Biol. 2015 Sep;36(10):8177-84. doi: 10.1007/s13277-015-3536-6. Epub 2015 May 21. PMID: 25990456 3:The preclinical evaluation of the dual mTORC1/2 inhibitor INK-128 as a potential anti-colorectal cancer agent. Li C, Cui JF, Chen MB, Liu CY, Liu F, Zhang QD, Zou J, Lu PH.Cancer Biol Ther. 2015;16(1):34-42. doi: 10.4161/15384047.2014.972274. PMID: 25692620 Free PMC Article4:The novel mTORC1/2 dual inhibitor INK-128 suppresses survival and proliferation of primary and transformed human pancreatic cancer cells. Lou HZ, Weng XC, Pan HM, Pan Q, Sun P, Liu LL, Chen B.Biochem Biophys Res Commun. 2014 Jul 25;450(2):973-8. doi: 10.1016/j.bbrc.2014.06.081. Epub 2014 Jun 24. PMID: 24971544