Indolmycin

• CAT Number: R005170
• CAS Number: 21200-24-8
• Molecular Formula: C14H15N3O2
• Molecular Weight: 257.293
• Purity: ≥95%
• Target: Antibiotic
• Solubility: Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
• Storage: -20°C
• IUPAC Name: (5S)-5-[(1R)-1-(1H-indol-3-yl)ethyl]-2-(methylamino)-1,3-oxazol-4-one
• InChI: InChI=1S/C14H15N3O2/c1-8(12-13(18)17-14(15-2)19-12)10-7-16-11-6-4-3-5-9(10)11/h3-8,12,16H,1-2H3,(H,15,17,18)/t8-,12+/m1/s1
• InChIKey: GNTVWGDQPXCYBV-PELKAZGASA-N
• SMILES: CC(C1C(=O)N=C(O1)NC)C2=CNC3=CC=CC=C32

Indolmycin(CAS 21200-24-8) is a highly selective antibiotic which acts as a tryptophan anti-metabolite. Recent research has shown that indolmycin is active against Mycobacteria and H. pylori, and can stimulate transcription in Escherichia coli.

Reference

1. J Bacteriol. 1983 Feb;153(2):1120-3.
Indolmycin-mediated inhibition and stimulation of transcription at the trp promoter of Escherichia coli.
Bogosian G, Haydock PV, Somerville RL.
Escherichia coli cells harboring a non-attenuated trp-lac operon fusion were used to evaluate the effects of indolmycin on the initiation of transcription at the trp promoter. Indolmycin caused repression in trpR+ strains and in trpR deletion mutants, although higher effector concentrations were required in the latter situation. Plasmid-mediated elevation in tryptophanyl-tRNA synthetase reversed the inhibitory effect of indolmycin. Indolmycin did not facilitate the binding of purified Trp repressor protein to trp operator DNA.