For research use only. Not for therapeutic Use.
IMB-301 (Cat No.: I045527) is a small-molecule inhibitor that blocks the intracellular trafficking of Shiga toxin by disrupting retrograde transport from early endosomes to the Golgi apparatus. By preventing toxin entry into the endoplasmic reticulum, IMB-301 effectively protects cells from Shiga toxin–induced cytotoxicity. It has been investigated as a potential therapeutic candidate for treating infections caused by Shiga toxin–producing bacteria, such as certain Escherichia coli strains. IMB-301 exemplifies host-directed strategies aimed at neutralizing bacterial virulence rather than directly targeting the pathogen.
| CAS Number | 64009-84-3 |
| Synonyms | 1-[2-(2,4-dichlorophenyl)-4-(4-fluorophenoxy)butyl]imidazole |
| Molecular Formula | C19H17Cl2FN2O |
| Purity | ≥95% |
| InChI | InChI=1S/C19H17Cl2FN2O/c20-15-1-6-18(19(21)11-15)14(12-24-9-8-23-13-24)7-10-25-17-4-2-16(22)3-5-17/h1-6,8-9,11,13-14H,7,10,12H2 |
| InChIKey | FHKXBOJPHOEMQO-UHFFFAOYSA-N |
| SMILES | C1=CC(=CC=C1OCCC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl)F |
| Reference | [1]. Ma L, et al. Identification of small molecule compounds targeting the interaction of HIV-1 Vif and human APOBEC3G by virtual screening and biological evaluation. Sci Rep. 2018;8(1):8067. Published 2018 May 23. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
