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Iloprost

Iloprost

  • CAT Number: I004892
  • CAS Number: 78919-13-8
  • Molecular Formula: C22H32O4
  • Molecular Weight: 360.5
  • Purity: ≥95%
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Iloprost (ZK 36374; CAT: I004892) is a synthetic analog of prostacyclin (PGI2), a naturally occurring substance in the body that plays a role in regulating blood vessel dilation and preventing blood clot formation. Iloprost mimics the effects of prostacyclin and acts as a potent vasodilator, promoting the relaxation of smooth muscle cells in blood vessels and improving blood flow. It is used in the treatment of various vascular conditions, including pulmonary arterial hypertension (PAH) and peripheral vascular disease (PVD). By enhancing vasodilation and inhibiting platelet aggregation, iloprost helps to improve symptoms and prevent further complications associated with these conditions.

Catalog Number I004892
CAS Number 78919-13-8
Molecular Formula

C22H32O4

Purity 95%
Target Prostanoid Receptors
Solubility 10 mM in DMSO
Storage Desiccate at -20C
Overview of Clinical Research

<span style=”color:#000000;”><span style=”font-family:arial,helvetica,sans-serif;”><span style=”font-size:12px;”>Iloprost is an e<span style=”font-variant-ligatures: normal; orphans: 2; widows: 2;”>poprostenol agonist.&nbsp;</span><span style=”font-variant-ligatures: normal; orphans: 2; widows: 2;”>CiVi Biopharma has received Orphan Drug status for Systemic scleroderma in USA in 2020.</span></span></span></span>

IUPAC Name (5E)-5-[(3aS,4R,5R,6aS)-5-hydroxy-4-[(E,3S)-3-hydroxy-4-methyloct-1-en-6-ynyl]-3,3a,4,5,6,6a-hexahydro-1H-pentalen-2-ylidene]pentanoic acid
InChI InChI=1S/C22H32O4/c1-3-4-7-15(2)20(23)11-10-18-19-13-16(8-5-6-9-22(25)26)12-17(19)14-21(18)24/h8,10-11,15,17-21,23-24H,5-7,9,12-14H2,1-2H3,(H,25,26)/b11-10+,16-8+/t15?,17-,18+,19-,20+,21+/m0/s1
InChIKey HIFJCPQKFCZDDL-ACWOEMLNSA-N
SMILES O[C@@H]1C[C@H](C/2)[C@H](CC2=CCCCC(O)=O)[C@H]1/C=C/[C@@H](O)C(C)CC#CC
Reference

<br />
1:Bone Marrow Aspirate Concentrate in Combination With Intravenous Iloprost Increases Bone Healing in Patients With Avascular Necrosis of the Femoral Head: A Matched Pair Analysis. Pilge H, Bittersohl B, Schneppendahl J, Hesper T, Zilkens C, Ruppert M, Krauspe R, J&auml;ger M.Orthop Rev (Pavia). 2017 Jan 4;8(4):6902. doi: 10.4081/or.2016.6902. eCollection 2016 Nov 17. PMID: 28507661 Free PMC Article<br />
2:Iloprost Instillation in Two Neonates with Pulmonary Hypertension. Unal S, Aktas S, Aksu M, Hirfanoglu IM, Atalay Y, Turkyilmaz C.J Coll Physicians Surg Pak. 2017 Apr;27(4):257-259. PMID: 28492159<br />
3:Effect of Topical Iloprost and Nitroglycerin on Gastric Microcirculation and Barrier Function during Hemorrhagic Shock in Dogs. Truse R, Hinterberg J, Schulz J, Herminghaus A, Weber A, Mettler-Altmann T, Bauer I, Picker O, Vollmer C.J Vasc Res. 2017;54(2):109-121. doi: 10.1159/000464262. Epub 2017 Apr 26. PMID: 28441653<br />
4:Decreased vasorelaxation induced by iloprost during acute inflammation in human internal mammary artery. Foudi N, Ozen G, Amgoud Y, Louedec L, Choqueux C, Badi A, Kotelevets L, Chastre E, Longrois D, Norel X.Eur J Pharmacol. 2017 Jun 5;804:31-37. doi: 10.1016/j.ejphar.2017.03.060. Epub 2017 Mar 31. PMID: 28373136<br />
5:Iloprost, prostaglandin E1, and papaverine relax human mesenteric arteries with similar potency. Mahlke C, K&uuml;hn JP, Mensel B, Schreiber A, Juretzko A, Steinbach A, Grisk O.Shock. 2017 Mar 30. doi: 10.1097/SHK.0000000000000866. [Epub ahead of print] PMID: 28362714<br />
6:Potential new treatment for non-freezing cold injury: is Iloprost the way forward? Ionescu AM, Hutchinson S, Ahmad M, Imray C.J R Army Med Corps. 2017 Mar 23. pii: jramc-2016-000672. doi: 10.1136/jramc-2016-000672. [Epub ahead of print] PMID: 28341787<br />
7:Iloprost Use in Patients with Persistent Intestinal Ischemia Unsuitable for Revascularization. Nuzzo A, Soudan D, Billiauws L, Bataille J, Maggiori L, Ronot M, Stocco J, Bouhnik Y, Castier Y, Corcos O; SURVI group..Ann Vasc Surg. 2017 Mar 18. pii: S0890-5096(17)30376-X. doi: 10.1016/j.avsg.2016.10.061. [Epub ahead of print] PMID: 28323233<br />
8:Investigation of Asymmetric and Symmetric Dimethylarginine Levels after Iloprost Treatment in Patients with Buerger/&#39;s Disease. Senol S, Senol A.Eur J Vasc Endovasc Surg. 2017 Mar;53(3):439-442. doi: 10.1016/j.ejvs.2016.12.017. Epub 2017 Jan 28. PMID: 28139409<br />
9:Treatment of Pulmonary Arterial Hypertension Using Initial Combination Therapy of Bosentan and Iloprost. Han X, Zhang Y, Dong L, Fang L, Chai Y, Niu M, Yu Y, Liu L, Yang X, Qu S, Li S.Respir Care. 2017 Apr;62(4):489-496. doi: 10.4187/respcare.05280. Epub 2017 Jan 24. PMID: 28119496<br />
10:Long-term survival of patients with critical limb ischemia treated with iloprost: response rate and predictive criteria. A retrospective analysis of 102 patients. Melillo E, Lucaccini E, Berchiolli R, Adami D, Nuti M, Dell/&#39;Omo G, Farina A, Panigada G, Roberts AT, Meini S.Eur Rev Med Pharmacol Sci. 2016 Dec;20(24):5233-5241. PMID: 28051243 Free Article

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