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iFSP1

iFSP1

  • CAT Number: I016161
  • CAS Number: 150651-39-1
  • Molecular Formula: C₂₀H₁₃N₅
  • Molecular Weight: 323.35
  • Purity: ≥95%
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iFSP1 (Cat No.:I016161) is a potent, selective, and glutathione-independent inhibitor of ferroptosis suppressor protein 1 (FSP1/AIFM2), with an EC50 value of 103nM. iFSP1 can selectively induce ferroptosis in GPX4 knockout Pfa1 cells and HT1080 cells overexpressing FSP1.

Catalog Number I016161
CAS Number 150651-39-1
Molecular Formula

C₂₀H₁₃N₅

Purity 95%
Storage Store at -20°C
IUPAC Name 1-amino-3-(4-methylphenyl)pyrido[1,2-a]benzimidazole-2,4-dicarbonitrile
InChI InChI=1S/C20H13N5/c1-12-6-8-13(9-7-12)18-14(10-21)19(23)25-17-5-3-2-4-16(17)24-20(25)15(18)11-22/h2-9H,23H2,1H3
InChIKey FNESYDFRCQEEKA-UHFFFAOYSA-N
SMILES CC1=CC=C(C=C1)C2=C(C3=NC4=CC=CC=C4N3C(=C2C#N)N)C#N
Reference

[1]. Doll S, et al. FSP1 is a glutathione-independent ferroptosis suppressor.Nature. 2019 Nov;575(7784):693-698.

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