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Idarubicin HCl

Idarubicin HCl

  • CAT Number: A001113
  • CAS Number: 57852-57-0
  • Molecular Formula: C26H27NO9 • HCl
  • Molecular Weight: 534
  • Purity: ≥95%
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Idarubicin HCl is a hydrochloride salt form of Idarubicin which is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells with IC50 of 3.3 ng/mL in a cell-free assay.<br>Idarubicin has significant cytotoxic activity against multicellular spheroids, comparable to the antiproliferative effects on monolayer cells.<br>Reduction of Idarubicin is dependent upon ketone reductases, and proceeds more stereoselectively than that of most ketones giving rise to the (13S)-epimer almost exclusively. The high stereospecificity in Idarubicin reduction might result from chiral induction due to the presence of asymmetric centres near to the carbonyl group in Idarubicin.

Catalog Number A001113
CAS Number 57852-57-0
Synonyms

4-demethoxydaunorubicin (NSC256439, 4-DMDR) HCl

Molecular Formula

C26H27NO9 • HCl

Purity 95%
Target Topoisomerase
Solubility >26.7mg/mL in DMSO
Storage 3 years -20C powder
InChIKey JVHPTYWUBOQMBP-RVFAQHLVSA-N

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