For research use only. Not for therapeutic Use.
icFSP1(CAT: I040523) is a potent and selective inhibitor of ferroptosis suppressor protein-1 (FSP1), designed to modulate ferroptotic cell death pathways. Unlike conventional enzyme inhibitors, icFSP1 does not act through competitive inhibition of FSP1’s enzymatic activity. Instead, it induces subcellular relocalization of FSP1 from the plasma membrane and promotes FSP1 condensation, effectively disabling its protective function against lipid peroxidation. This mechanism acts synergistically with GPX4 inhibition, making icFSP1 a powerful tool for probing ferroptosis and enhancing anticancer strategies that exploit oxidative stress vulnerabilities. Ideal for use in redox biology, cancer research, and ferroptosis-targeted drug discovery.
| CAS Number | 1115910-36-5 |
| Synonyms | N-[4-(2-methyl-4-oxoquinazolin-3-yl)phenyl]-2-(3,4,5-trimethoxyphenyl)acetamide |
| Molecular Formula | C26H25N3O5 |
| Purity | ≥95% |
| IUPAC Name | N-[4-(2-methyl-4-oxoquinazolin-3-yl)phenyl]-2-(3,4,5-trimethoxyphenyl)acetamide |
| InChI | InChI=1S/C26H25N3O5/c1-16-27-21-8-6-5-7-20(21)26(31)29(16)19-11-9-18(10-12-19)28-24(30)15-17-13-22(32-2)25(34-4)23(14-17)33-3/h5-14H,15H2,1-4H3,(H,28,30) |
| InChIKey | QLTZGMMQMVZODD-UHFFFAOYSA-N |
| SMILES | CC1=NC2=CC=CC=C2C(=O)N1C3=CC=C(C=C3)NC(=O)CC4=CC(=C(C(=C4)OC)OC)OC |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
