Icaritin

• CAT Number: I000659
• CAS Number: 118525-40-9
• Molecular Formula: C21H20O6
• Molecular Weight: 368.4
• Purity: ≥95%
• Solubility: DMSO: ≤ 14 mg/mL
• Storage: Store at -20°C
• IUPAC Name: 3,5,7-trihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)chromen-4-one
• InChI: InChI=1S/C21H20O6/c1-11(2)4-9-14-15(22)10-16(23)17-18(24)19(25)20(27-21(14)17)12-5-7-13(26-3)8-6-12/h4-8,10,22-23,25H,9H2,1-3H3
• InChIKey: TUUXBSASAQJECY-UHFFFAOYSA-N
• SMILES: CC(=CCC1=C2C(=C(C=C1O)O)C(=O)C(=C(O2)C3=CC=C(C=C3)OC)O)C

Icaritin (Cat.No:I000659) is a prenylflavonoid compound derived from the herb Epimedium brevicornum. It has attracted attention for its potential anticancer properties, particularly in inhibiting the proliferation and inducing apoptosis in various cancer cell lines. Icaritin is being investigated for its therapeutic potential in cancer treatment and has shown promising results in preclinical studies.

Reference

1:Glucuronidation of icaritin by human liver microsomes, human intestine microsomes and expressed UDP-glucuronosyltransferase enzymes: identification of UGT1A3, 1A9 and 2B7 as the main contributing enzymes. Wang L, Hong X, Yao Z, Dai Y, Zhao G, Qin Z, Wu B, Gonzalez FJ, Yao X.Xenobiotica. 2017 May 15:1-11. doi: 10.1080/00498254.2017.1323139. [Epub ahead of print] PMID: 28443723 2:Oral absorption, distribution, metabolism, and excretion of icaritin in rats by Q-TOF and UHPLC-MS/MS. Zhang SQ, Zhang SZ.Drug Test Anal. 2017 Mar 17. doi: 10.1002/dta.2188. [Epub ahead of print] PMID: 28303675 3:Icaritin, a novel plant-derived osteoinductive agent, enhances the osteogenic differentiation of human bone marrow- and human adipose tissue-derived mesenchymal stem cells. Wu T, Shu T, Kang L, Wu J, Xing J, Lu Z, Chen S, Lv J.Int J Mol Med. 2017 Apr;39(4):984-992. doi: 10.3892/ijmm.2017.2906. Epub 2017 Feb 24. PMID: 28260001 4:[Effect of Icaritin on Proliferation and Apoptosis of THP-1 Cell and Its Mechanism]. Kuang WY, Zheng MC, Zhang GS, Li RJ.Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2017 Feb;25(1):94-98. doi: 10.7534/j.issn.1009-2137.2017.01.016. Chinese. PMID: 28245382 5:Identification of sphingosine kinase 1 (SphK1) as a primary target of icaritin in hepatocellular carcinoma cells. Lu PH, Chen MB, Liu YY, Wu MH, Li WT, Wei MX, Liu CY, Qin SK.Oncotarget. 2017 Apr 4;8(14):22800-22810. doi: 10.18632/oncotarget.15205. PMID: 28206952 Free PMC Article6:AMPK-autophagy inhibition sensitizes icaritin-induced anti-colorectal cancer cell activity. Zhou C, Gu J, Zhang G, Dong D, Yang Q, Chen MB, Xu D.Oncotarget. 2017 Feb 28;8(9):14736-14747. doi: 10.18632/oncotarget.14718. PMID: 28103582 Free PMC Article7:Icaritin enhances mESC self-renewal through upregulating core pluripotency transcription factors mediated by ERα. Tsang WP, Zhang F, He Q, Cai W, Huang J, Chan WY, Shen Z, Wan C.Sci Rep. 2017 Jan 16;7:40894. doi: 10.1038/srep40894. PMID: 28091581 Free PMC Article8:Icaritin Reduces Oral Squamous Cell Carcinoma Progression via the Inhibition of STAT3 Signaling. Yang JG, Lu R, Ye XJ, Zhang J, Tan YQ, Zhou G.Int J Mol Sci. 2017 Jan 12;18(1). pii: E132. doi: 10.3390/ijms18010132. PMID: 28085115 Free PMC Article9:Icaritin induces apoptotic and autophagic cell death in human glioblastoma cells. Li Z, Meng X, Jin L.Am J Transl Res. 2016 Nov 15;8(11):4628-4643. eCollection 2016. PMID: 27904667 Free PMC Article10:Anticancer effect of icaritin inhibits cell growth of colon cancer through reactive oxygen species, Bcl-2 and cyclin D1/E signaling. Li C, Peng W, Song X, Wang Q, Wang W.Oncol Lett. 2016 Nov;12(5):3537-3542. Epub 2016 Sep 5. PMID: 27900033 Free PMC Article