ICA

• CAT Number: I013044
• CAS Number: 3374-88-7
• Molecular Formula: C₁₃H₁₀N₄S
• Molecular Weight: 254.31
• Purity: ≥95%
• Target: Parasite
• Solubility: DMSO
• Storage: Store at -20°C
• IUPAC Name: N,4-dipyridin-2-yl-1,3-thiazol-2-amine
• InChI: InChI=1S/C13H10N4S/c1-3-7-14-10(5-1)11-9-18-13(16-11)17-12-6-2-4-8-15-12/h1-9H,(H,15,16,17)
• InChIKey: RYCUBTFYRLAMFA-UHFFFAOYSA-N
• SMILES: C1=CC=NC(=C1)C2=CSC(=N2)NC3=CC=CC=N3

ICA (N-(pyridine-2-yl)-4-(pyridine-2-yl)thiazol-2-amine)（Cat No.:I013044） is a compound that acts as an inhibitor of SK channels. It has been found to possess activity against Leishmania, a parasitic protozoan that causes leishmaniasis. ICA demonstrates an IC50 (half maximal inhibitory concentration) of 2.1 µM against Leishmania, indicating its effectiveness in inhibiting the growth or survival of the parasite.

Reference

[1]. Bhuniya D, et al. Aminothiazoles: Hit to lead development to identify antileishmanial agents. Eur J Med Chem. 2015 Sep 18;102:582-93.[2]. Skibsbye L, et al. Antiarrhythmic Mechanisms of SK Channel Inhibition in the Rat Atrium. J Cardiovasc Pharmacol. 2015 Aug;66(2):165-76.