IC87201

• CAT Number: I005215
• CAS Number: 866927-10-8
• Molecular Formula: C13H10Cl2N4O
• Molecular Weight: 309.15
• Purity: ≥95%
• Solubility: DMSO: ≥ 28 mg/mL
• Storage: 3 years -20C powder
• IUPAC Name: 2-[(2H-benzotriazol-5-ylamino)methyl]-4,6-dichlorophenol
• InChI: InChI=1S/C13H10Cl2N4O/c14-8-3-7(13(20)10(15)4-8)6-16-9-1-2-11-12(5-9)18-19-17-11/h1-5,16,20H,6H2,(H,17,18,19)
• InChIKey: QEHVTUCLCBXQIC-UHFFFAOYSA-N
• SMILES: OC1=C(Cl)C=C(Cl)C=C1CNC2=CC=C(NN=N3)C3=C2

IC87201 (CAT: I005215) is an inhibitor of PSD95-nNOS (postsynaptic density protein 95-neuronal nitric oxide synthase) protein-protein interactions. By inhibiting this interaction, IC87201 suppresses NMDAR (N-methyl-D-aspartate receptor)-dependent nitric oxide (NO) and cyclic guanosine monophosphate (cGMP) formation. This inhibition can have implications for modulating neuronal signaling and synaptic plasticity. The compound has been used in research to investigate the role of PSD95-nNOS interactions and their impact on NMDAR-mediated signaling pathways.

Reference

1:Sci Rep. 2015 Jul 16;5:12157. doi: 10.1038/srep12157. Biochemical investigations of the mechanism of action of small molecules ZL006 and IC87201 as potential inhibitors of the nNOS-PDZ/PSD-95-PDZ interactions.Bach A,Pedersen SW,Dorr LA,Vallon G,Ripoche I,Ducki S,Lian LY, PMID: 26177569 PMCID: PMC4503980 DOI: 10.1038/srep12157
Abstract: ZL006 and IC87201 have been presented as efficient inhibitors of the nNOS/PSD-95 protein-protein interaction and shown great promise in cellular experiments and animal models of ischemic stroke and pain. Here, we investigate the proposed mechanism of action of ZL006 and IC87201 using biochemical and biophysical methods, such as fluorescence polarization (FP), isothermal titration calorimetry (ITC), and (1)H-(15)N HSQC NMR. Our data show that under the applied in vitro conditions, ZL006 and IC87201 do not interact with the PDZ domains of nNOS or PSD-95, nor inhibit the nNOS-PDZ/PSD-95-PDZ interface by interacting with the β-finger of nNOS-PDZ. Our findings have implications for further medicinal chemistry efforts of ZL006, IC87201 and analogues, and challenge the general and widespread view on their mechanism of action.