Ibutilide Fumarate

• CAT Number: A001208
• CAS Number: 122647-32-9
• Molecular Formula: C44H76N4O10S2
• Molecular Weight: 885.23
• Purity: ≥95%
• Synonyms: U-70226E
• Target: Sodium Channel
• Solubility: >25.6mg/mL in DMSO
• Storage: 3 years -20C powder
• IUPAC Name: (E)-but-2-enedioic acid;N-[4-[4-[ethyl(heptyl)amino]-1-hydroxybutyl]phenyl]methanesulfonamide
• InChI: InChI=1S/2C20H36N2O3S.C4H4O4/c2*1-4-6-7-8-9-16-22(5-2)17-10-11-20(23)18-12-14-19(15-13-18)21-26(3,24)25;5-3(6)1-2-4(7)8/h2*12-15,20-21,23H,4-11,16-17H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;;2-1+
• InChIKey: PCIOHQNIRPWFMV-WXXKFALUSA-N
• SMILES: CCCCCCCN(CC)CCCC(C1=CC=C(C=C1)NS(=O)(=O)C)O.CCCCCCCN(CC)CCCC(C1=CC=C(C=C1)NS(=O)(=O)C)O.C(=CC(=O)O)C(=O)O

Ibutilide Fumarate (Cat. No: A001208), a class III antiarrhythmic drug with novel ion channel activity, has become the first choice of cardioversion for recent atrial fibrillation and atrial flutter.

Reference

1:Pharmacokinetic and pharmacodynamic properties of a single intravenous dose of ibutilide fumarate: a phase I, randomized, open-label, increasing-dose study in healthy Chinese men. Li Y, Tian L, Huang Y, Hua L.Clin Ther. 2007 Sep;29(9):1957-66. PMID: 18035195 2:Efficacy and safety of ibutilide fumarate for the conversion of atrial arrhythmias after cardiac surgery. VanderLugt JT, Mattioni T, Denker S, Torchiana D, Ahern T, Wakefield LK, Perry KT, Kowey PR.Circulation. 1999 Jul 27;100(4):369-75. PMID: 10421596 Free Article3:Erythematous bullous lesions on the dorsa of the hands due to contact exposure to ibutilide fumarate for injection. Dodds ES, Oberg KC.Pharmacotherapy. 1998 Jul-Aug;18(4):880-2. PMID: 9692669 4:Developmental toxicity of ibutilide fumarate in rats after oral administration. Marks TA, Terry RD.Teratology. 1996 Sep;54(3):157-64. PMID: 8987159 5:Effects of ibutilide fumarate, a novel antiarrhythmic agent, and its enantiomers on isolated rabbit myocardium. Cimini MG, Brunden MN, Gibson JK.Eur J Pharmacol. 1992 Nov 3;222(1):93-8. PMID: 1361444