Ibuproxam

• CAT Number: I007246
• CAS Number: 53648-05-8
• Molecular Formula: C13H19NO2
• Molecular Weight: 221.3
• Purity: ≥95%
• Solubility: Soluble in DMSO
• Storage: Store at -20°C
• IUPAC Name: N-hydroxy-2-[4-(2-methylpropyl)phenyl]propanamide
• InChI: InChI=1S/C13H19NO2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(15)14-16/h4-7,9-10,16H,8H2,1-3H3,(H,14,15)
• InChIKey: BYPIURIATSUHDW-UHFFFAOYSA-N
• SMILES: CC(C)CC1=CC=C(C=C1)C(C)C(=O)NO

Ibuproxam (Cat.No:I007246), also known as Ibuproxamum and G-277, is a nonsteroidal antiinflammatory drug (NSAID) used to treat musculoskeletal pain, arthritis, and soft-tissue disorders.

Reference

1:Characterization of ibuproxam binary and ternary dispersions with hydrophilic carriers. Cirri M, Mura P, Rabasco AM, Ginés JM, Moyano JR, Gònzalez-Rodrìguez ML.Drug Dev Ind Pharm. 2004 Jan;30(1):65-74. PMID: 15000431 2:Comparative study of ibuproxam complexation with amorphous beta-cyclodextrin derivatives in solution and in the solid state. Mura P, Zerrouk N, Faucci M, Maestrelli F, Chemtob C.Eur J Pharm Biopharm. 2002 Sep;54(2):181-91. PMID: 12191690 3:Effects of the host cavity size and the preparation method on the physicochemical properties of ibuproxam-cyclodextrin systems. Mura P, Adragna E, Rabasco AM, Moyano JR, Pérez-Martìnez JI, Arias MJ, Ginés JM.Drug Dev Ind Pharm. 1999 Mar;25(3):279-87. PMID: 10071820 4:Compatibility study between ibuproxam and pharmaceutical excipients using differential scanning calorimetry, hot-stage microscopy and scanning electron microscopy. Mura P, Faucci MT, Manderioli A, Bramanti G, Ceccarelli L.J Pharm Biomed Anal. 1998 Oct;18(1-2):151-63. PMID: 9863953 5:Anti-inflammatory, analgesic and ulcerogenic properties of S-(+)-ibuproxam, racemic ibuproxam-beta-cyclodextrin and S-(+)-ibuproxam-beta-cyclodextrin. Bole-Vunduk B, Verhnjak K, Zmitek J.J Pharm Pharmacol. 1996 Nov;48(11):1153-7. PMID: 8961164 6:Photocontact dermatitis from ketoprofen with cross-reactivity to ibuproxam. Cusano F, Capozzi M.Contact Dermatitis. 1992 Jul;27(1):50-1. No abstract available. PMID: 1424592 7:Contact allergy to ibuproxam. Molinini R.Contact Dermatitis. 1991 Apr;24(4):302-3. No abstract available. PMID: 1831108 8:Contact dermatitis from ibuproxam. A case with cross-reactivity with ketoprofen. Valsecchi R, Cainelli T.Contact Dermatitis. 1990 Jan;22(1):51. No abstract available. PMID: 2138957 9:Use of 1H NMR spectroscopy in the selection of the mobile phase for high-performance liquid chromatographic monitoring of the synthesis of ibuproxam. Zmitek J, Stendler T, Rusjakovski B, Kocjan D, Boznar B.J Chromatogr. 1989 Apr 21;467(1):276-8. No abstract available. PMID: 2753938 10:Contact dermatitis to ibuproxam. Mozzanica N, Pucci M, Negri M, Pigatto P.Contact Dermatitis. 1987 May;16(5):281-2. No abstract available. PMID: 2957156