Ibrutinib deacryloylpiperidine

• CAT Number: I014818
• CAS Number: 330786-24-8
• Molecular Formula: C₁₇H₁₃N₅O
• Molecular Weight: 303.32
• Purity: ≥95%
• Storage: Room temperature
• IUPAC Name: 3-(4-phenoxyphenyl)-2H-pyrazolo[3,4-d]pyrimidin-4-amine
• InChI: InChI=1S/C17H13N5O/c18-16-14-15(21-22-17(14)20-10-19-16)11-6-8-13(9-7-11)23-12-4-2-1-3-5-12/h1-10H,(H3,18,19,20,21,22)
• InChIKey: YYVUOZULIDAKRN-UHFFFAOYSA-N
• SMILES: C1=CC=C(C=C1)OC2=CC=C(C=C2)C3=C4C(=NC=NC4=NN3)N

Ibrutinib intermediate N-2 (Cat No.: I014818) is a highly selective and irreversible inhibitor of Bruton’s tyrosine kinase (BTK). Ibrutinib intermediate N-2 is an organic synthesis intermediate and pharmaceutical intermediate, which can be used in the laboratory research and development process and chemical pharmaceutical synthesis process, mainly as the raw material drug ibrutinib intermediate.

Reference

[1]. Somana Siva Prasad, et al. A QUALITY BY DESIGN APPROACH FOR DEVELOPMENT OF SIMPLE AND ROBUST REVERSED PHASE STABILITY INDICATING HPLC METHOD FOR ESTIMATION OF IBRUTINIB AND ITS IMPURITIES.[2]. Honigberg LA, et al. The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy. Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):13075-80.