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Ibrutinib-biotin

Ibrutinib-biotin

  • CAT Number: I002031
  • CAS Number: 1599432-18-4
  • Molecular Formula: C56H80N12O9S
  • Molecular Weight: 1097.37
  • Purity: ≥95%
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Ibrutinib-biotin (Cat.No:I002031) is a bioconjugate compound that combines the kinase inhibitor ibrutinib with a biotin moiety. This conjugate allows for targeted delivery of ibrutinib to cells expressing biotin receptors, potentially enhancing its therapeutic efficacy. Ibrutinib-biotin has been explored as a strategy to improve the selectivity and effectiveness of ibrutinib-based therapies.

Catalog Number I002031
CAS Number 1599432-18-4
Molecular Formula

C56H80N12O9S

Purity 95%
Target 0.755-1.02 nM (BTK), 1.71-2.29 nM (TEC), 3.66-4.27 nM (BLK), 4.42-5.57 nM (BMX), 5.99-6.92 nM (LCK), 33.8-36.3 nM (Src), 0.187-0.198 μM (ITK),5.34-4.87 μM (JAK3)[1]
Solubility 10 mM in DMSO
Storage Desiccate at -20C
Reference

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<br>[1]. Betty Y. CHANG, et al. Companion diagnostics for tec family kinase inhibitor therapy. WO 2014059368 A1.

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