IBR2

• CAT Number: I019948
• CAS Number: 313526-24-8
• Molecular Formula: C₂₄H₂₀N₂O₂S
• Molecular Weight: 400.49
• Purity: ≥95%
• Storage: Store at -20°C
• IUPAC Name: 2-benzylsulfonyl-1-(1H-indol-3-yl)-1H-isoquinoline
• InChI: InChI=1S/C24H20N2O2S/c27-29(28,17-18-8-2-1-3-9-18)26-15-14-19-10-4-5-11-20(19)24(26)22-16-25-23-13-7-6-12-21(22)23/h1-16,24-25H,17H2
• InChIKey: YCOHEPDJLXZVBZ-UHFFFAOYSA-N
• SMILES: C1=CC=C(C=C1)CS(=O)(=O)N2C=CC3=CC=CC=C3C2C4=CNC5=CC=CC=C54

IBR2（Cat No.:I019948） is a highly potent and selective inhibitor of RAD51, a key protein involved in DNA double-strand break repair. By disrupting RAD51 multimerization and promoting its degradation through the proteasome, IBR2 effectively impairs RAD51-mediated DNA repair processes. This inhibition of RAD51 activity leads to the accumulation of DNA damage, inhibits cancer cell growth, and induces apoptosis. The specific targeting of RAD51 by IBR2 highlights its potential as a therapeutic agent for cancer treatment, particularly in combination with DNA-damaging agents or other DNA repair inhibitors.

Reference

[1]. Jiewen Zhu, et al. A novel small molecule RAD51 inactivator overcomes imatinib-resistance in chronic myeloid leukaemia. EMBO Mol Med. 2013 Mar;5(3):353-65.[2]. Zhu J, et al. Synthesis, molecular modeling, and biological evaluation of novel RAD51 inhibitors. Eur J Med Chem. 2015;96:196-208.