IACS-010759

• CAT Number: I020093
• CAS Number: 1570496-34-2
• Molecular Formula: C₂₅H₂₅F₃N₆O₄S
• Molecular Weight: 562.56
• Purity: ≥95%
• Storage: Store at -20°C
• IUPAC Name: 5-[5-methyl-1-[[3-(4-methylsulfonylpiperidin-1-yl)phenyl]methyl]-1,2,4-triazol-3-yl]-3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazole
• InChI: InChI=1S/C25H25F3N6O4S/c1-16-29-23(24-30-22(32-38-24)18-6-8-20(9-7-18)37-25(26,27)28)31-34(16)15-17-4-3-5-19(14-17)33-12-10-21(11-13-33)39(2,35)36/h3-9,14,21H,10-13,15H2,1-2H3
• InChIKey: HWJWNWZJUYCGKV-UHFFFAOYSA-N
• SMILES: CC1=NC(=NN1CC2=CC(=CC=C2)N3CCC(CC3)S(=O)(=O)C)C4=NC(=NO4)C5=CC=C(C=C5)OC(F)(F)F

IACS-010759（Cat No.:I020093）, also known as IACS-10759, is a potent and selective inhibitor of oxidative phosphorylation. It demonstrates an impressive IC50 value of less than 10 nM. By inhibiting complex I, IACS-010759 effectively prevents cellular respiration, disrupting the energy production process. This inhibition has the potential to selectively target and impair the metabolism of cancer cells, which heavily rely on oxidative phosphorylation for their energy needs.

Reference

[1]. Protopopova M. IACS-10759: A novel OXPHOS inhibitor which selectively kill tumors with metabolic vulnerabilities. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 4380. doi:10.1158/1538-7445.AM2015-4380