IACS-010759 hydrochloride

• CAT Number: I019764
• CAS Number: 1807523-99-4
• Molecular Formula: C₂₅H₂₆ClF₃N₆O₄S
• Molecular Weight: 599.02
• Purity: ≥95%
• Storage: Store at -20°C
• IUPAC Name: 5-[5-methyl-1-[[3-(4-methylsulfonylpiperidin-1-yl)phenyl]methyl]-1,2,4-triazol-3-yl]-3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazole;hydrochloride
• InChI: InChI=1S/C25H25F3N6O4S.ClH/c1-16-29-23(24-30-22(32-38-24)18-6-8-20(9-7-18)37-25(26,27)28)31-34(16)15-17-4-3-5-19(14-17)33-12-10-21(11-13-33)39(2,35)36;/h3-9,14,21H,10-13,15H2,1-2H3;1H
• InChIKey: LUSCFOVOISLXTM-UHFFFAOYSA-N
• SMILES: CC1=NC(=NN1CC2=CC(=CC=C2)N3CCC(CC3)S(=O)(=O)C)C4=NC(=NO4)C5=CC=C(C=C5)OC(F)(F)F.Cl

IACS-010759 (Cat No.:I019764) hydrochloride is a powerful compound that effectively inhibits complex I, a critical component of oxidative phosphorylation (OXPHOS). By targeting complex I, IACS-010759 hydrochloride disrupts the normal flow of electron transport and ultimately hinders ATP synthesis, which is vital for cellular energy production. This inhibition has significant implications for various biological processes and may hold potential in therapeutic interventions targeting conditions where modulating OXPHOS is beneficial.

Reference

[1]. Protopopova M. IACS-10759: A novel OXPHOS inhibitor which selectively kill tumors with metabolic vulnerabilities. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 4380. doi:10.1158/1538-7445.AM2015-4380