IA9 TFA

• CAT Number: I040205
• Molecular Formula: C51H88N10O10.xC2HF3O2
• Molecular Weight: 1001.31 (free acid)
• Purity: ≥95%

IA9 TFA (CAT: I040205) is a peptide-based inhibitor of TREM-2 (Triggering Receptor Expressed on Myeloid cells 2), designed to modulate innate immune responses. By blocking TREM-2 activity, IA9 TFA effectively reduces the release of proinflammatory cytokines and has demonstrated significant anti-inflammatory effects in preclinical models. In the collagen-induced arthritis (CIA) mouse model, IA9 TFA markedly suppressed joint inflammation and tissue damage, highlighting its potential as a therapeutic candidate for autoimmune and inflammatory diseases. This compound is a valuable tool for studying TREM-2 signaling in neuroinflammation, osteoimmunology, and chronic inflammatory conditions.

Reference

[1]. Sigalov AB. Inhibition of TREM-2 Markedly Suppresses Joint Inflammation and Damage in Experimental Arthritis. Int J Mol Sci. 2022;23(16):8857. Published 2022 Aug 9.
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