Tenapanor HCl

  • CAT Number: I009752
  • CAS Number: 1234365-97-9 (2HCl)
  • Molecular Formula: C50H68Cl6N8O10S2
  • Molecular Weight: 1217.96
  • Purity: ≥95%
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Tenapanor HCl (CAT: I009752) is an inhibitor of the sodium-proton (Na(+)/H(+)) exchanger NHE3. NHE3 is involved in regulating sodium absorption and fluid balance in the gastrointestinal tract and kidneys. By inhibiting NHE3, tenapanor reduces sodium absorption, leading to increased excretion of sodium in the stool. This mechanism of action results in decreased intestinal sodium absorption, leading to potential therapeutic applications in conditions such as irritable bowel syndrome with constipation (IBS-C) and chronic kidney disease.

Catalog Number I009752
CAS Number 1234365-97-9 (2HCl)
Synonyms

AZD-1722; AZD 1722; AZD1722; RDX 5791; RDX-5791; RDX5791; Tenapanor; Tenapanor hydrochloride; Tenapanor dihydrochloride;3-((S)-6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)-N-(26-((3-((S)-6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinoli

Molecular Formula

C50H68Cl6N8O10S2

Purity 95%
Target Na+/H+ exchanger 3 (NHE3) inhibitor
Solubility Soluble in DMSO and water
Storage 0 - 4 °C for short term, or -20 °C for long term
InChI InChI=1S/C50H66Cl4N8O10S2.2ClH/c1-61-31-43(41-27-37(51)29-47(53)45(41)33-61)35-7-5-9-39(25-35)73(65,66)59-15-19-71-23-21-69-17-13-57-49(63)55-11-3-4-12-56-50(64)58-14-18-70-22-24-72-20-16-60-74(67,68)40-10-6-8-36(26-40)44-32-62(2)34-46-42(44)28-38(52)30-4
InChIKey VFRAXTZDILCRKY-OWRGXFNZSA-N
SMILES O=S(C1=CC=CC([C@@H]2CN(C)CC3=C2C=C(Cl)C=C3Cl)=C1)(NCCOCCOCCNC(NCCCCNC(NCCOCCOCCNS(=O)(C4=CC=CC([C@@H]5CN(C)CC6=C5C=C(Cl)C=C6Cl)=C4)=O)=O)=O)=O.[H]Cl.[H]Cl
Reference

</br>1: Johansson SA, Knutsson M, Leonsson-Zachrisson M, Rosenbaum DP. Effect of Food Intake on the Pharmacodynamics of Tenapanor: A Phase 1 Study. Clin Pharmacol Drug Dev. 2017 Mar 24. doi: 10.1002/cpdd.341. [Epub ahead of print] PubMed PMID: 28339149.</br>2: Johansson S, Rosenbaum DP, Ahlqvist M, Rollison H, Knutsson M, Stefansson B, Elebring M. Effects of Tenapanor on Cytochrome P450-Mediated Drug-Drug Interactions. Clin Pharmacol Drug Dev. 2017 Mar 16. doi: 10.1002/cpdd.346. [Epub ahead of print] PubMed PMID: 28301096.

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