For research use only. Not for therapeutic Use.
I942(CAT: I029015) is a first-in-class, selective non-cyclic nucleotide (NCN) EPAC1 agonist, specifically designed to activate Exchange Protein directly Activated by cAMP 1 (EPAC1) without engaging PKA pathways. By selectively targeting EPAC1, I942 enables precise modulation of cAMP signaling, distinguishing its action from traditional cAMP analogs. It has demonstrated the ability to attenuate proinflammatory cytokine signaling, a pathway commonly implicated in cardiovascular diseases, including atherosclerosis and myocardial injury. I942 is a valuable chemical probe for investigating EPAC1-specific signaling and therapeutic potential in inflammation, cardiovascular pathology, and immune regulation.
| CAS Number | 868145-09-9 |
| Synonyms | N-(2,4-dimethylphenyl)sulfonyl-2-naphthalen-2-yloxyacetamide |
| Molecular Formula | C20H19NO4S |
| Purity | ≥95% |
| IUPAC Name | N-(2,4-dimethylphenyl)sulfonyl-2-naphthalen-2-yloxyacetamide |
| InChI | InChI=1S/C20H19NO4S/c1-14-7-10-19(15(2)11-14)26(23,24)21-20(22)13-25-18-9-8-16-5-3-4-6-17(16)12-18/h3-12H,13H2,1-2H3,(H,21,22) |
| InChIKey | KCRXXSQZEZOCFM-UHFFFAOYSA-N |
| SMILES | CC1=CC(=C(C=C1)S(=O)(=O)NC(=O)COC2=CC3=CC=CC=C3C=C2)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
