Crisaborole (AN2728)

  • CAT Number: I006297
  • CAS Number: 906673-24-3
  • Molecular Formula: C14H10BNO3
  • Molecular Weight: 251.0451
Inquiry Now

Crisaborole, also known as AN-2728, is a topically administered, boron-containing, anti-inflammatory compound that inhibits PDE4 activity and thereby suppresses the release of TNFalpha, IL-12, IL-23 and other cytokines. At the time of publication, three phase Ib clinical trials, a IIa trial and a IIb trial of AN-2728 in patients with psoriasis had been completed; the compound was also undergoing phase II development for atopic dermatitis, but no data were available for this indication.

Catalog Number I006297
CAS Number 906673-24-3
Molecular Formula


Purity 95%
Target PDE4 inhibitor
Solubility Soluble in DMSO, not in water
Storage 0 - 4°C for short term ,or -20 °C for long term
Related CAS (or 906673-25-4)
Overview of Clinical Research

Originator: Anacor Pharmaceuticals<br />
Class: Anti-inflammatories; Antipsoriatics; Heterocyclic bicyclo compounds; Nitriles; Nonsteroidal anti-inflammatories; Organic boron compounds; Phenyl ethers; Small molecules<br />
Mechanism of Action: Type 4 cyclic nucleotide phosphodiesterase inhibitors<br />
Orphan Drug Status: No<br />
New Molecular Entity: Yes<br />

InChI InChI=1S/C14H10BNO3/c16-8-10-1-4-12(5-2-10)19-13-6-3-11-9-18-15(17)14(11)7-13/h1-7,17H,9H2

Request a Quote

Contact Us at MuseChem

We are committed to providing you with reliable, cost-effective solutions for your chemical needs, while ensuring your safety and comfort. Our team of experts is always available to answer your questions and help you navigate the complexities of the chemical industry.

Whether you're looking for a specific product or need help with a custom synthesis project, we're here to help you discover a new world of chemical possibilities. Contact us today to learn more about how we can assist you with all of your chemical needs.

Our goal is to make the process of ordering chemicals as seamless and hassle-free as possible. Let us know how we can assist you, and we'll get back to you as soon as possible. We look forward to hearing from you!