Crisaborole (AN2728)

  • CAT Number: I006297
  • CAS Number: 906673-24-3
  • Molecular Formula: C14H10BNO3
  • Molecular Weight: 251.0451
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Crisaborole, also known as AN-2728, is a topically administered, boron-containing, anti-inflammatory compound that inhibits PDE4 activity and thereby suppresses the release of TNFalpha, IL-12, IL-23 and other cytokines. At the time of publication, three phase Ib clinical trials, a IIa trial and a IIb trial of AN-2728 in patients with psoriasis had been completed; the compound was also undergoing phase II development for atopic dermatitis, but no data were available for this indication.

Catalog Number I006297
CAS Number 906673-24-3
Molecular Formula

C14H10BNO3

Purity 95%
Target PDE4 inhibitor
Solubility Soluble in DMSO, not in water
Storage 0 - 4°C for short term ,or -20 °C for long term
Related CAS (or 906673-25-4)
Overview of Clinical Research

Originator: Anacor Pharmaceuticals<br />
Class: Anti-inflammatories; Antipsoriatics; Heterocyclic bicyclo compounds; Nitriles; Nonsteroidal anti-inflammatories; Organic boron compounds; Phenyl ethers; Small molecules<br />
Mechanism of Action: Type 4 cyclic nucleotide phosphodiesterase inhibitors<br />
Orphan Drug Status: No<br />
New Molecular Entity: Yes<br />

InChI InChI=1S/C14H10BNO3/c16-8-10-1-4-12(5-2-10)19-13-6-3-11-9-18-15(17)14(11)7-13/h1-7,17H,9H2
InChIKey IQBSCLXAECVABP-UHFFFAOYSA-N
SMILES N#CC1=CC=C(OC2=CC=C3C(B(O)OC3)=C2)C=C1

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