HZ-1157

• CAT Number: I007235
• CAS Number: 1009734-33-1
• Molecular Formula: C12H16N4O
• Molecular Weight: 232.287
• Purity: ≥95%
• Target: HCV Protease
• Solubility: Soluble in DMSO
• Storage: Store at -20°C
• IUPAC Name: 5-[(2-methylpropan-2-yl)oxy]quinazoline-2,4-diamine
• InChI: InChI=1S/C12H16N4O/c1-12(2,3)17-8-6-4-5-7-9(8)10(13)16-11(14)15-7/h4-6H,1-3H3,(H4,13,14,15,16)
• InChIKey: JQHKDYFLRJIBLX-UHFFFAOYSA-N
• SMILES: CC(C)(C)OC1=CC=CC2=C1C(=NC(=N2)N)N

HZ-1157 (Cat.No:I007235) is a small molecule inhibitor that targets the enzyme dihydroorotate dehydrogenase (DHODH), a key enzyme in the de novo pyrimidine synthesis pathway. By inhibiting DHODH, HZ-1157 disrupts DNA and RNA synthesis, leading to the inhibition of cell proliferation. It is being investigated for its potential in the treatment of various cancers and autoimmune diseases.

Reference

1:Yu Y, Jing JF, Tong XK, He PL, Li YC, Hu YH, Tang W, Zuo JP. Discovering novel anti-HCV compounds with inhibitory activities toward HCV NS3/4A protease. Acta Pharmacol Sin. 2014 Aug;35(8):1074-81. doi: 10.1038/aps.2014.55. PubMed PMID: 25066323; PubMed Central PMCID: PMC4125721.