Hydroxypropyl Starch

• CAT Number: M006676
• CAS Number: 9049-76-7
• Molecular Formula: (C6H10O5)n
• Purity: ≥95%
• Storage: -20°C
• IUPAC Name: 5-[6-[[3,4-dihydroxy-6-(hydroxymethyl)-5-methoxyoxan-2-yl]oxymethyl]-5-[3-(2,3-dihydroxy-2-methylpropoxy)-4-hydroxy-6-(hydroxymethyl)-5-methoxyoxan-2-yl]oxy-3,4-dihydroxyoxan-2-yl]oxy-6-(hydroxymethyl)-2-methyloxane-3,4-diol
• InChI: InChI=1S/C31H56O22/c1-11-16(36)17(37)25(14(7-34)48-11)52-29-21(41)19(39)26(15(51-29)8-46-28-20(40)18(38)23(44-3)12(5-32)49-28)53-30-27(47-10-31(2,43)9-35)22(42)24(45-4)13(6-33)50-30/h11-30,32-43H,5-10H2,1-4H3
• InChIKey: VYIPQJQYDCRXMM-UHFFFAOYSA-N
• SMILES: CC1C(C(C(C(O1)CO)OC2C(C(C(C(O2)COC3C(C(C(C(O3)CO)OC)O)O)OC4C(C(C(C(O4)CO)OC)O)OCC(C)(CO)O)O)O)O)O

Hydroxypropyl Starch(CAT: M006676) is a significant compound in the field of pharmaceuticals, particularly in the development of drug delivery systems and as an excipient in pharmaceutical formulations. This chemical is a modified starch, where hydroxypropyl groups are introduced onto the starch molecule, altering its properties. Hydroxypropyl Starch serves as a valuable pharmaceutical ingredient, primarily as a binder, disintegrant, or controlled-release matrix in oral solid dosage forms.

Reference

1: Zhang L, Wang Y, Liu H, Yu L, Liu X, Chen L, Zhang N. Developing hydroxypropyl methylcellulose/hydroxypropyl starch blends for use as capsule materials. Carbohydr Polym. 2013 Oct 15;98(1):73-9. doi: 10.1016/j.carbpol.2013.05.070. Epub 2013 May 31. PubMed PMID: 23987318.
2: Wu Q, Lin DQ, Yao SJ. Evaluation of poly(ethylene glycol)/hydroxypropyl starch aqueous two-phase system for immunoglobulin G extraction. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Jun 1;928:106-12. doi: 10.1016/j.jchromb.2013.03.020. Epub 2013 Mar 26. PubMed PMID: 23603297.
3: Wu Q, Lin DQ, Zhang QL, Gao D, Yao SJ. Evaluation of a PEG/hydroxypropyl starch aqueous two-phase system for the separation of monoclonal antibodies from cell culture supernatant. J Sep Sci. 2014 Feb;37(4):447-53. doi: 10.1002/jssc.201300894. Epub 2014 Jan 6. PubMed PMID: 24318171.
4: Wen H, Hu J, Ge H, Zou S, Xiao Y, Li Y, Feng H, Fan L. Preparation and characterization of aminoethyl hydroxypropyl starch modified with collagen peptide. Int J Biol Macromol. 2017 Aug;101:996-1003. doi: 10.1016/j.ijbiomac.2017.03.131. Epub 2017 Mar 27. PubMed PMID: 28359887.
5: Brobst KM, Tai H. Determination of chlorohydrins in hydroxypropyl starch ethers. J Assoc Off Anal Chem. 1971 Sep;54(5):1093-4. PubMed PMID: 5151665.
6: Wang Y, Zhang L, Liu H, Yu L, Simon GP, Zhang N, Chen L. Relationship between morphologies and mechanical properties of hydroxypropyl methylcellulose/hydroxypropyl starch blends. Carbohydr Polym. 2016 Nov 20;153:329-35. doi: 10.1016/j.carbpol.2016.07.029. Epub 2016 Jul 17. PubMed PMID: 27561503.
7: Liu S, Cai P, Li X, Chen L, Li L, Li B. Effect of film multi-scale structure on the water vapor permeability in hydroxypropyl starch (HPS)/Na-MMT nanocomposites. Carbohydr Polym. 2016 Dec 10;154:186-93. doi: 10.1016/j.carbpol.2016.08.006. Epub 2016 Aug 4. PubMed PMID: 27577909.