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Hydroxy-PEG6-CH2-Boc

Hydroxy-PEG6-CH2-Boc

  • CAT Number: I016585
  • CAS Number: 297162-47-1
  • Molecular Formula: C₁₈H₃₆O₉
  • Molecular Weight: 396.47
  • Purity: ≥95%
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Hydroxy-PEG6-CH2-Boc(CAT: I016585) stands as a vital building block in the synthesis of PROTACs (Proteolysis-Targeting Chimeras). This PEG-based linker integrates a hydroxy group and a Boc (tert-butyloxycarbonyl) protecting group, enabling its incorporation into the design of bifunctional molecules. By facilitating the conjugation of target-binding ligands and E3 ligase-recruiting moieties, Hydroxy-PEG6-CH2-Boc plays a pivotal role in constructing PROTACs that harness the cellular degradation machinery to selectively eliminate disease-associated proteins.

Catalog Number I016585
CAS Number 297162-47-1
Molecular Formula

C₁₈H₃₆O₉

Purity 95%
Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

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