Hydroxy-PEG2-acid

• CAT Number: I016413
• CAS Number: 1334286-77-9
• Molecular Formula: C₇H₁₄O₅
• Molecular Weight: 178.18
• Purity: ≥95%

Hydroxy-PEG2-acid (CAT: I016413) is a PEG-based PROTAC linker designed for use in the synthesis of PROTACs. PROTACs are molecules used in targeted protein degradation strategies, where they act as a bridge between a target protein of interest and an E3 ligase. This linker can be utilized to connect the target protein-binding moiety and the ligand for the E3 ligase, facilitating the recruitment of the E3 ligase to the target protein. The design of PROTACs allows for the specific degradation of the target protein, leading to potential therapeutic applications in various fields, including drug development and disease treatment.

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.