Hydrocortisone acetate

• CAT Number: I000005
• CAS Number: 50-03-3
• Molecular Formula: C23H32O6
• Molecular Weight: 404.5
• Purity: ≥95%
• Solubility: DMSO:38mg/mL
• Storage: -20°C
• InChI: InChI=1S/C23H32O6/c1-13(24)29-12-19(27)23(28)9-7-17-16-5-4-14-10-15(25)6-8-21(14,2)20(16)18(26)11-22(17,23)3/h10,16-18,20,26,28H,4-9,11-12H2,1-3H3/t16-,17-,18-,20+,21-,22-,23-/m0/s1
• InChIKey: ALEXXDVDDISNDU-JZYPGELDSA-N
• SMILES: CC(OCC([C@@]1(O)CC[C@@H]2[C@]1(C)C[C@H](O)[C@H]3[C@H]2CCC4=CC(CC[C@]34C)=O)=O)=O

Hydrocortisone acetate (Cat.No:I000005) is a corticosteroid, used to decrease swelling, itching, and pain that is caused by minor skin irritations or by hemorrhoids.

Reference

1:Development and Validation of a Stability Indicating RP-HPLC Method for Hydrocortisone Acetate Active Ingredient, Propyl Parahydroxybenzoate and Methyl Parahydroxybenzoate Preservatives, Butylhydroxyanisole Antioxidant, and Their Degradation Products in a Rectal Gel Formulation. Ascaso M, Pérez-Lozano P, García M, García-Montoya E, Miñarro M, Ticó JR, Fàbregas A, Carrillo C, Sarrate R, Suñé-Negre JM.J AOAC Int. 2015 Jan-Feb;98(1):27-34. doi: 10.5740/jaoacint.13-411. PMID: 25857875 2:Development and optimization of a capillary zone electrophoresis technique for simultaneous determination of miconazole nitrate and hydrocortisone acetate in a cream pharmaceutical formulation. Korany MA, Maher HM, Galal SM, Ragab MA.J AOAC Int. 2013 Nov-Dec;96(6):1295-301. PMID: 24645507 3:Validation of a thin-layer chromatography for the determination of hydrocortisone acetate and lidocaine in a pharmaceutical preparation. Dołowy M, Kulpińska-Kucia K, Pyka A.ScientificWorldJournal. 2014 Jan 6;2014:107879. doi: 10.1155/2014/107879. eCollection 2014. PMID: 24526880 Free PMC Article4:Hydrocortisone acetate alone or combined with mupirocin for atopic dermatitis in infants under two years of age – a randomized double blind pilot trial. Canpolat F, Erkoçoğlu M, Tezer H, Kocabaş CN, Kandi B.Eur Rev Med Pharmacol Sci. 2012 Dec;16(14):1989-93. PMID: 23242727 Free Article5:A β-cyclodextrin, polyethyleneimine and silk fibroin hydrogel containing Centella asiatica extract and hydrocortisone acetate: releasing properties and in vivo efficacy for healing of pressure sores. Lee MS, Seo SR, Kim JC.Clin Exp Dermatol. 2012 Oct;37(7):762-71. doi: 10.1111/j.1365-2230.2011.04331.x. Epub 2012 Mar 22. PMID: 22439751 6:Absorption of hydrocortisone acetate in human connective tissue using phonophoresis. Gurney AB, Wascher D, Schenck R, Tennison A, Jaramillo B.Sports Health. 2011 Jul;3(4):346-51. PMID: 23016027 Free PMC Article7:Efficacy and onset of action of hydrocortisone acetate 2.5% and pramoxine hydrochloride 1% lotion for the management of pruritus: results of a pilot study. Kircik LH.J Clin Aesthet Dermatol. 2011 Feb;4(2):48-50. PMID: 21386957 Free PMC Article8:Efficacy of hydrocortisone acetate/hyaluronidase vs triamcinolone acetonide/hyaluronidase in the treatment of oral submucous fibrosis. Singh M, Niranjan HS, Mehrotra R, Sharma D, Gupta SC.Indian J Med Res. 2010 May;131:665-9. PMID: 20516538 9:Optimization and validation of an RP-HPLC method for analysis of hydrocortisone acetate and lidocaine in suppositories. Jancic-Stojanović B, Malenović A, Marković S, Ivanović D, Medenica M.J AOAC Int. 2010 Jan-Feb;93(1):102-7. PMID: 20334171 10:Antimicrobial activity of iodoquinol 1%-hydrocortisone acetate 2% gel against ciclopirox and clotrimazole. Burnett BP, Mitchell CM.Cutis. 2008 Oct;82(4):273-80. PMID: 19055171