Hydrocortisone 21-Propionate

• CAT Number: C000889
• CAS Number: 6677-98-1
• Molecular Formula: C₂₄H₃₄O₆
• Molecular Weight: 418.52
• Purity: ≥95%
• Synonyms: (11β)-11,17-Dihydroxy-21-(1-oxopropoxy)pregn-4-ene-3,20-dione; Cortisol 21-Propionate; Hydrocortisone Propionate
• Solubility: Ethanol (Slightly), Methanol (Slightly)
• Storage: -20°C, Hygroscopic
• IUPAC Name: [2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] propanoate
• InChI: InChI=1S/C24H34O6/c1-4-20(28)30-13-19(27)24(29)10-8-17-16-6-5-14-11-15(25)7-9-22(14,2)21(16)18(26)12-23(17,24)3/h11,16-18,21,26,29H,4-10,12-13H2,1-3H3/t16-,17-,18-,21+,22-,23-,24-/m0/s1
• InChIKey: MRECAIZOMKKXOZ-RPPPWEFESA-N
• SMILES: CCC(=O)OCC(=O)C1(CCC2C1(CC(C3C2CCC4=CC(=O)CCC34C)O)C)O

Hydrocortisone 21-Propionate (Cat No.:C000889) is a synthetic corticosteroid and a derivative of hydrocortisone (cortisol), which is a natural hormone produced by the adrenal glands. As a glucocorticoid, hydrocortisone 21-propionate possesses anti-inflammatory, immunosuppressive, and antipruritic properties. It is commonly used in topical preparations, such as creams, ointments, and lotions, for the treatment of various skin conditions, including eczema, dermatitis, and psoriasis. The propionate ester modification improves its skin penetration and efficacy.

Reference

Mason, J. et al.: Br. J. Dermatol., 146, 351 (2002); Sears, H.W. et al.: Clin. Therap., 19, 710 (1997); Otomo, Y.Z. et al.: Nip. Yakur. Zas., 78, 647 (1981); Kitano, Y., et al.: Acta Derm-Venereol., 66, 98 (1986)