Hydralazine

  • CAT Number: I028959
  • CAS Number: 86-54-4
  • Molecular Formula: C8H8N4
  • Molecular Weight: 160.18
  • Purity: 98%
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Hydralazine (Cat.No:I028959) is an antihypertensive medication that relaxes and dilates blood vessels, thereby reducing blood pressure. It is commonly used to treat hypertension and heart failure. Hydralazine works by directly relaxing the smooth muscles in the blood vessel walls, resulting in increased blood flow and decreased vascular resistance.


Catalog Number I028959
CAS Number 86-54-4
Synonyms

Apresolin, Apressin, Aprezolin, Hydralazine

Molecular Formula C8H8N4
Purity 98%
Solubility Soluble in DMSO
Appearance Solid powder
Storage Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
IUPAC Name 1-Hydrazinophthalazine
InChI 1S/C8H8N4/c9-11-8-7-4-2-1-3-6(7)5-10-12-8/h1-5H,9H2,(H,11,12)
InChIKey RPTUSVTUFVMDQK-UHFFFAOYSA-N
SMILES c12c(cn[nH]c1=N/N)cccc2
Reference

1: Nyolczas N, Dékány M, Muk B, Szabó B. Combination of Hydralazine and Isosorbide-Dinitrate in the Treatment of Patients with Heart Failure with Reduced Ejection Fraction. Adv Exp Med Biol. 2018;1067:31-45. doi: 10.1007/5584_2017_112. Review. PubMed PMID: 29086392.
2: Yao L, Wu YT, Tian GX, Xia CQ, Zhang F, Zhang W. Acrolein Scavenger Hydralazine Prevents Streptozotocin-Induced Painful Diabetic Neuropathy and Spinal Neuroinflammation in Rats. Anat Rec (Hoboken). 2017 Oct;300(10):1858-1864. doi: 10.1002/ar.23618. Epub 2017 Jul 25. PubMed PMID: 28598552.
3: Chatard M, Puech C, Roche F, Perek N. Hypoxic Stress Induced by Hydralazine Leads to a Loss of Blood-Brain Barrier Integrity and an Increase in Efflux Transporter Activity. PLoS One. 2016 Jun 23;11(6):e0158010. doi: 10.1371/journal.pone.0158010. eCollection 2016. PubMed PMID: 27337093; PubMed Central PMCID: PMC4919080.
4: Flynn JT, Bradford MC, Harvey EM. Intravenous Hydralazine in Hospitalized Children and Adolescents with Hypertension. J Pediatr. 2016 Jan;168:88-92. doi: 10.1016/j.jpeds.2015.07.070. Epub 2015 Sep 1. PubMed PMID: 26340877.
5: Harati H, Rahmani M, Taghizadeh S. Acute Cholestatic Liver Injury From Hydralazine Intake. Am J Ther. 2016 Sep-Oct;23(5):e1211-4. doi: 10.1097/MJT.0000000000000310. PubMed PMID: 26291593.
6: Ostrye J, Hailpern SM, Jones J, Egan B, Chessman K, Shatat IF. The efficacy and safety of intravenous hydralazine for the treatment of hypertension in the hospitalized child. Pediatr Nephrol. 2014 Aug;29(8):1403-9. doi: 10.1007/s00467-014-2772-0. Epub 2014 Feb 20. PubMed PMID: 24554119.

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