HWL-088

• CAT Number: I017739
• CAS Number: 2378617-96-8
• Molecular Formula: C22H19FO4
• Molecular Weight: 366.38
• Purity: ≥95%
• Synonyms: 2-[2-fluoro-4-[[3-(2-methylphenyl)phenyl]methoxy]phenoxy]acetic acid
• InChI: InChI=1S/C22H19FO4/c1-15-5-2-3-8-19(15)17-7-4-6-16(11-17)13-26-18-9-10-21(20(23)12-18)27-14-22(24)25/h2-12H,13-14H2,1H3,(H,24,25)
• InChIKey: NJYJBYPNDWNZAH-UHFFFAOYSA-N
• SMILES: CC1=CC=CC=C1C2=CC=CC(=C2)COC3=CC(=C(C=C3)OCC(=O)O)F

HWL-088（Cat No.:I017739）is a potent and selective inhibitor of cyclin-dependent kinase 9 (CDK9), a key regulator of transcriptional elongation through phosphorylation of RNA polymerase II. By targeting CDK9, HWL-088 suppresses transcription of genes critical for cell survival and proliferation, particularly those driven by oncogenes. This compound is a valuable research tool for studying transcriptional regulation, apoptosis, and cancer biology. Its ability to modulate transcriptional addiction makes it relevant in exploring therapeutic strategies for hematologic malignancies and solid tumors, where CDK9 signaling plays a pivotal role.