D609

• CAT Number: I005004
• CAS Number: 83373-60-8
• Molecular Formula: C11H15OS2 • K
• Molecular Weight: 266.5
• Purity: ≥95%
• Target: PC-PLC
• Solubility: DMSO：＞ 10 mM
• Storage: Store at -20°C
• IC50: 6.4 uM (Ki)
• IUPAC Name: potassium;8-tricyclo[5.2.1.02,6]decanyloxymethanedithioate
• InChI: InChI=1S/C11H16OS2.K/c13-11(14)12-10-5-6-4-9(10)8-3-1-2-7(6)8;/h6-10H,1-5H2,(H,13,14);/q;+1/p-1
• InChIKey: IGULCCCBGBDZKQ-UHFFFAOYSA-M
• SMILES: [S-]C(OC1CC2C(CCC3)C3C1C2)=S.[K+]

D609 (Cat.No:I005004) is a chemical compound with potential therapeutic applications. It acts as an inhibitor of phosphatidylcholine-specific phospholipase C (PC-PLC), a key enzyme involved in cellular signaling pathways. D609 has been studied for its anti-inflammatory and anticancer properties. Further research is ongoing to explore its efficacy and potential clinical uses. 

Reference

1:Effect of D609 on the expression of GADD45β protein: Potential inhibitory role in the growth of glioblastoma cancer stem like cells. Kalluri HS, Kuo JS, Dempsey RJ.Eur J Pharmacol. 2016 Nov 15;791:510-517. doi: 10.1016/j.ejphar.2016.09.026. Epub 2016 Sep 20. PMID: 27658347 2:Cell lipid metabolism modulators 2-bromopalmitate, D609, monensin, U18666A and probucol shift discoidal HDL formation to the smaller-sized particles: implications for the mechanism of HDL assembly. Quach D, Vitali C, La FM, Xiao AX, Millar JS, Tang C, Rader DJ, Phillips MC, Lyssenko NN.Biochim Biophys Acta. 2016 Dec;1861(12 Pt A):1968-1979. doi: 10.1016/j.bbalip.2016.09.017. Epub 2016 Sep 24. PMID: 27671775 3:What Is the True Structure of D609, a Widely Used Lipid Related Enzyme Inhibitor? Kato M, Hammam MA, Taniguchi T, Suga Y, Monde K.Org Lett. 2016 Feb 19;18(4):768-71. doi: 10.1021/acs.orglett.6b00025. Epub 2016 Feb 8. PMID: 26854352 4:D609-mediated inhibition of ATP synthesis in neural progenitor cells. Kalluri HS, Dempsey RJ.Neuroreport. 2014 Jul 9;25(10):777-81. doi: 10.1097/WNR.0000000000000176. PMID: 24918458 Free PMC Article5:Regulation of neural progenitor cell proliferation by D609: potential role for ERK. Kalluri HS, Gusain A, Dempsey RJ.Mol Neurobiol. 2013 Apr;47(2):782-9. doi: 10.1007/s12035-012-8390-6. Epub 2012 Dec 30. PMID: 23275176 6:The tricyclodecan-9-yl-xanthogenate D609 triggers ceramide increase and enhances FasL-induced caspase-dependent and -independent cell death in T lymphocytes. Milhas D, Andrieu-Abadie N, Levade T, Benoist H, Ségui B.Int J Mol Sci. 2012;13(7):8834-52. doi: 10.3390/ijms13078834. Epub 2012 Jul 16. PMID: 22942738 Free PMC Article7:Anti-proliferative effects of tricyclodecan-9-yl-xanthogenate (D609) involve ceramide and cell cycle inhibition. Gusain A, Hatcher JF, Adibhatla RM, Wesley UV, Dempsey RJ.Mol Neurobiol. 2012 Jun;45(3):455-64. doi: 10.1007/s12035-012-8254-0. Epub 2012 Mar 14. Erratum in: Mol Neurobiol. 2012 Jun;45(3):465. PMID: 22415444 Free PMC Article8:Tricyclodecan-9-yl-xanthogenate (D609) mechanism of actions: a mini-review of literature. Adibhatla RM, Hatcher JF, Gusain A.Neurochem Res. 2012 Apr;37(4):671-9. doi: 10.1007/s11064-011-0659-z. Epub 2011 Nov 22. Review. PMID: 22101393 Free PMC Article9:D609 inhibits the proliferation of neural progenitor cells. Kalluri HS, Dempsey RJ.Neuroreport. 2010 Jul 14;21(10):700-3. PMID: 20568314 10:Protection by D609 through cell-cycle regulation after stroke. Adibhatla RM, Hatcher JF.Mol Neurobiol. 2010 Jun;41(2-3):206-17. doi: 10.1007/s12035-010-8100-1. Epub 2010 Feb 12. PMID: 20148315