For research use only. Not for therapeutic Use.
HTH-02-006(CAT: I028920) is a potent and selective inhibitor of NUAK2, a serine/threonine kinase downstream of the Hippo-YAP signaling pathway, with an IC₅₀ of 126 nM. In cellular models such as HuCCT-1 cells, HTH-02-006 reduces phosphorylated MYPT1 levels, indicating effective NUAK2 pathway inhibition. Functionally, it suppresses YAP-driven cell proliferation, hepatomegaly, and tumorigenesis, making it a valuable tool for cancer research. Additionally, HTH-02-006 exhibits antifibrotic properties, offering potential utility in fibrosis-related disease models. This compound is ideal for investigating NUAK2-mediated signaling, YAP-associated oncogenesis, and fibrotic disease progression.
| Synonyms | N-[3-[5-iodo-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]propanamide |
| Molecular Formula | C25H29IN6O3 |
| Purity | ≥95% |
| IUPAC Name | N-[3-[5-iodo-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]propanamide |
| InChI | InChI=1S/C25H29IN6O3/c1-4-23(33)28-17-6-5-7-19(14-17)35-24-20(26)16-27-25(30-24)29-21-9-8-18(15-22(21)34-3)32-12-10-31(2)11-13-32/h5-9,14-16H,4,10-13H2,1-3H3,(H,28,33)(H,27,29,30) |
| InChIKey | KQMWYEJQANQTDM-UHFFFAOYSA-N |
| SMILES | CCC(=O)NC1=CC(=CC=C1)OC2=NC(=NC=C2I)NC3=C(C=C(C=C3)N4CCN(CC4)C)OC |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
