For research use only. Not for therapeutic Use.
HSD1590（Cat No.:I015532）is an investigational small-molecule inhibitor of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), an enzyme that catalyzes the conversion of cortisone to active cortisol within tissues. By blocking 11β-HSD1, HSD1590 reduces intracellular cortisol levels, thereby modulating glucose metabolism, insulin sensitivity, and inflammatory responses. It has been explored as a therapeutic candidate for type 2 diabetes, obesity, and metabolic syndrome, where excess cortisol activity contributes to disease progression. HSD1590 serves as a valuable research tool in endocrinology, metabolic disease research, and drug discovery targeting glucocorticoid regulation.
| CAS Number | 2379279-96-4 |
| Synonyms | [2-methoxy-3-(4,5,10-triazatetracyclo[7.7.0.02,6.012,16]hexadeca-1(9),2(6),3,7,10,12(16)-hexaen-11-yl)phenyl]boronic acid |
| Molecular Formula | C20H18BN3O3 |
| Purity | ≥95% |
| IUPAC Name | [2-methoxy-3-(4,5,10-triazatetracyclo[7.7.0.02,6.012,16]hexadeca-1(9),2(6),3,7,10,12(16)-hexaen-11-yl)phenyl]boronic acid |
| InChI | InChI=1S/C20H18BN3O3/c1-27-20-13(6-3-7-15(20)21(25)26)19-12-5-2-4-11(12)18-14-10-22-24-16(14)8-9-17(18)23-19/h3,6-10,25-26H,2,4-5H2,1H3,(H,22,24) |
| InChIKey | WTZMCUOBQPTERK-UHFFFAOYSA-N |
| SMILES | B(C1=C(C(=CC=C1)C2=NC3=C(C4=C2CCC4)C5=C(C=C3)NN=C5)OC)(O)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
