HS38

• CAT Number: I011927
• CAS Number: 1030203-81-6
• Molecular Formula: C14H12ClN5O2S
• Molecular Weight: 349.79
• Purity: ≥95%
• Target: Inhibitor for DAPK1 and ZIPK
• Solubility: Soluble in DMSO
• Storage: Store at 2-8°C
• IUPAC Name: 2-[[1-(3-chlorophenyl)-4-oxo-2H-pyrazolo[3,4-d]pyrimidin-6-yl]sulfanyl]propanamide
• InChI: InChI=1S/C14H12ClN5O2S/c1-7(11(16)21)23-14-18-12-10(13(22)19-14)6-17-20(12)9-4-2-3-8(15)5-9/h2-7,17H,1H3,(H2,16,21)
• InChIKey: BDVPSWBRXLWRCV-UHFFFAOYSA-N
• SMILES: CC(C(=O)N)SC1=NC(=O)C2=CNN(C2=N1)C3=CC(=CC=C3)Cl

HS38（Cat No.:I011927） is a potent and selective inhibitor that targets two kinases: DAPK1 and ZIPK (DAPK3). It demonstrates a high affinity for these kinases, with Kd values of 300nM and 280nM, respectively. Additionally, HS38 acts as an inhibitor of PIM3, with an IC50 of 200nM. This compound has potential applications in the research of smooth muscle-related diseases, suggesting its relevance in investigating and potentially treating such conditions. The specific targeting of DAPK1, ZIPK, and PIM3 makes HS38 a valuable tool in studying the functions of these kinases and their associated pathways.

Reference

1: MacDonald JA, Sutherland C, Carlson DA, Bhaidani S, Al-Ghabkari A, Swärd K, Haystead TA, Walsh MP. A Small Molecule Pyrazolo[3,4-d]Pyrimidinone Inhibitor of Zipper-Interacting Protein Kinase Suppresses Calcium Sensitization of Vascular Smooth Muscle. Mol Pharmacol. 2016 Jan;89(1):105-17. doi: 10.1124/mol.115.100529. Epub 2015 Oct 13. PubMed PMID: 26464323.2: Carlson DA, Franke AS, Weitzel DH, Speer BL, Hughes PF, Hagerty L, Fortner CN, Veal JM, Barta TE, Zieba BJ, Somlyo AV, Sutherland C, Deng JT, Walsh MP, MacDonald JA, Haystead TA. Fluorescence linked enzyme chemoproteomic strategy for discovery of a potent and selective DAPK1 and ZIPK inhibitor. ACS Chem Biol. 2013 Dec 20;8(12):2715-23. doi: 10.1021/cb400407c. Epub 2013 Oct 17. PubMed PMID: 24070067; PubMed Central PMCID: PMC4445880.3: Lorenz E, Lastovica A, Owen RJ. Subtyping of Campylobacter jejuni Penner serotypes 9, 38 and 63 from human infections, animals and water by pulsed field gel electrophoresis and flagellin gene analysis. Lett Appl Microbiol. 1998 Mar;26(3):179-82. PubMed PMID: 9569705.